Team game results -- 2021 Chicago White Sox
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | Decision | Save | Versus | T |
| 4/8/2021 | | |  Mtl | L | 9-13 | | Puk | L | Puk | | Bumgarner | L |
| 4/8/2021 | | @ |  Sea | W | 4-2 | | Puk | L | Diehl | Rogers,Ty | Paxton | L |
| 4/9/2021 | | | Mtl | L | 2-3 | | Ohtani | R | Fairbanks | | Lopez,P | R |
| 4/9/2021 | | @ | Sea | W | 4-2 | | Ohtani | R | Ohtani | Barnes,M | Odorizzi | R |
| 4/10/2021 | | | Mtl | W | 4-2 | | Giolito | R | Giolito | Oberg | Yarbrough | L |
| 4/10/2021 | | @ | Sea | L | 4-5 | | Wood,A | L | Fairbanks | | Gonzales | L |
| 4/11/2021 | | | Mtl | W | 10-2 | | Wood,A | L | Wood,A | | Dobnak | R |
| 4/11/2021 | | @ | Sea | L | 1-5 | | Porcello | R | Porcello | | Samardzija | R |
| 4/12/2021 | | |  Tor | L | 6-8 | | Porcello | R | Porcello | | Sharp | R |
| 4/12/2021 | | @ |  Cle | L | 5-6 | 11 | Giolito | R | Barnes,M | | Woodruff | R |
| 4/13/2021 | | | Tor | L | 3-7 | | Puk | L | Puk | | Yamaguchi | R |
| 4/13/2021 | | @ | Cle | L | 3-5 | | Puk | L | Puk | | Verlander | R |
| 4/14/2021 | | | Tor | W | 6-2 | | Ohtani | R | Ohtani | | Smyly | L |
| 4/14/2021 | | @ | Cle | W | 4-3 | | Ohtani | R | Ohtani | Oberg | Hendricks | R |
| 4/16/2021 | | |  Min | L | 1-3 | | Giolito | R | Oberg | | Gallen | R |
| 4/16/2021 | | @ |  Det | L | 0-9 | | Wood,A | L | Wood,A | | Fulmer,M | R |
| 4/17/2021 | | | Min | L | 2-5 | | Wood,A | L | Wood,A | | Ray,R | L |
| 4/17/2021 | | @ | Det | W | 3-1 | | Porcello | R | Porcello | Oberg | Sheffield,Ju | L |
| 4/18/2021 | | | Min | W | 3-1 | | Puk | L | Puk | Oberg | Paddack | R |
| 4/18/2021 | | @ | Det | L | 3-4 | | Puk | L | Fairbanks | | Happ,J.A. | L |
| 4/23/2021 | | |  Phi | W | 4-1 | | Bassitt | R | Bassitt | Oberg | Chirinos,Y | R |
| 4/24/2021 | | | Phi | W | 7-4 | | Giolito | R | Giolito | | Jefferies | R |
| 4/25/2021 | | | Phi | L | 1-4 | | Porcello | R | Porcello | | Bieber | R |
| 4/27/2021 | | |  Pit | L | 3-5 | | Wood,A | L | Diehl | | Perez,Ma | L |
| 4/28/2021 | | | Pit | L | 3-12 | | Lester,Jon | L | Lester,Jon | | Allen,L | L |
| 4/29/2021 | | | Pit | L | 0-1 | | Bassitt | R | Bassitt | | Senzatela | R |
| 5/3/2021 | | @ |  NYY | W | 3-2 | | Lester,Jon | L | Lester,Jon | Bleier | Bundy | R |
| 5/3/2021 | | |  Tex | W | 6-2 | | Bassitt | R | Bassitt | | Gomber | L |
| 5/4/2021 | | @ | NYY | W | 4-0 | | Wood,A | L | Wood,A | | Minor | L |
| 5/4/2021 | | | Tex | W | 6-4 | | Giolito | R | Giolito | Bleier | Agrazal | R |
| 5/5/2021 | | @ | NYY | L | 3-6 | | Porcello | R | Porcello | | Lamet | R |
| 5/5/2021 | | | Tex | L | 4-9 | | Porcello | R | Porcello | | King | R |
| 5/6/2021 | | @ | NYY | L | 2-5 | | Bassitt | R | Bleier | | Javier | R |
| 5/6/2021 | | | Tex | W | 10-2 | | Wood,A | L | Wood,A | | Matz | L |
| 5/7/2021 | | @ |  Ari | L | 2-3 | | Giolito | R | Giolito | | Mahle | R |
| 5/8/2021 | | @ | Ari | L | 0-5 | | Lester,Jon | L | Lester,Jon | | Lynn | R |
| 5/9/2021 | | @ | Ari | W | 6-5 | | Wood,A | L | Wood,A | Oberg | Gray,Jon | R |
| 5/11/2021 | | @ |  SDP | W | 6-5 | | Porcello | R | Bowman | Oberg | Maeda | R |
| 5/12/2021 | | @ | SDP | L | 3-4 | | Bassitt | R | Hughes | | Peacock,B | R |
| 5/13/2021 | | @ | SDP | W | 9-3 | | Lester,Jon | L | Lester,Jon | | Nola,Aa | R |
| 5/24/2021 | | @ |  Bos | W | 10-6 | | Chatwood | R | Chatwood | Bleier | Margevicius | L |
| 5/24/2021 | | |  KCR | L | 4-5 | | Bassitt | R | Bassitt | | Wilson,Bry | R |
| 5/25/2021 | | @ | Bos | W | 6-2 | | Porcello | R | Porcello | | Romano,S | R |
| 5/25/2021 | | | KCR | W | 8-3 | | Chatwood | R | Diehl | | Hudson,Dak | R |
| 5/26/2021 | | @ | Bos | L | 2-3 | | Bassitt | R | Bleier | | Rodriguez,E | L |
| 5/26/2021 | | | KCR | L | 2-5 | | Lester,Jon | L | Lester,Jon | | Fried | L |
| 5/27/2021 | | @ | Bos | W | 9-5 | | Lester,Jon | L | Lester,Jon | | Smeltzer | L |
| 5/27/2021 | | | KCR | W | 4-2 | | Porcello | R | Porcello | Oberg | Quintana,J | L |
| 5/28/2021 | | @ | Tor | L | 8-13 | | Giolito | R | Giolito | | Lambert,P | R |
| 5/28/2021 | | | Cle | W | 4-3 | | Giolito | R | Rogers,Ty | | Woodruff | R |
| 5/29/2021 | | @ | Tor | L | 5-20 | | Chatwood | R | Chatwood | | Freeland | L |
| 5/29/2021 | | | Cle | L | 2-3 | 13 | Bassitt | R | Bleier | | Verlander | R |
| 5/30/2021 | | @ | Tor | W | 4-2 | | Porcello | R | Diehl | Barnes,M | Reid-Foley | R |
| 5/30/2021 | | | Cle | L | 1-10 | | Chatwood | R | Chatwood | | Hendricks | R |
| 6/1/2021 | | | Sea | L | 4-7 | | Lester,Jon | L | Bleier | | Paxton | L |
| 6/1/2021 | | @ |  Was | W | 6-5 | | Bassitt | R | Bassitt | Barnes,M | Kuhl | R |
| 6/2/2021 | | | Sea | L | 5-6 | | Porcello | R | Diehl | | Odorizzi | R |
| 6/2/2021 | | @ | Was | L | 1-7 | | Lester,Jon | L | Lester,Jon | | Barria | R |
| 6/3/2021 | | | Sea | W | 9-3 | | Giolito | R | Giolito | | Samardzija | R |
| 6/3/2021 | | @ | Was | L | 2-6 | | Giolito | R | Giolito | | Burnes | R |
| 6/4/2021 | | | Sea | W | 9-3 | | Bassitt | R | Bassitt | | Gonzales | L |
| 6/4/2021 | | @ | Was | W | 6-4 | 10 | Chatwood | R | Diehl | Barnes,M | McKay,B | L |
| 6/8/2021 | | |  NYM | L | 7-15 | | Porcello | R | Porcello | | Anderson,I | R |
| 6/9/2021 | | | NYM | L | 4-10 | | Giolito | R | Giolito | | Gausman | R |
| 6/10/2021 | | | NYM | L | 1-4 | | Ohtani | R | Ohtani | | Cueto | R |
| 6/11/2021 | | |  Atl | W | 14-2 | | Chatwood | R | Chatwood | | Singer,B | R |
| 6/12/2021 | | | Atl | W | 10-9 | 14 | Lester,Jon | L | Bleier | | Santana,De | R |
| 6/13/2021 | | | Atl | L | 2-6 | | Porcello | R | Fairbanks | | Marquez | R |
| 6/15/2021 | | |  Mia | L | 5-8 | 10 | Giolito | R | Oberg | | Alcantara,Sa | R |
| 6/16/2021 | | | Mia | L | 1-2 | | Ohtani | R | Rogers,Ty | | Arrieta | R |
| 6/17/2021 | | | Mia | W | 5-3 | | Chatwood | R | Chatwood | Rogers,Ty | Wright,K | R |
| 6/18/2021 | | @ |  SFG | L | 1-3 | | Ohtani | R | Ohtani | | Wheeler | R |
| 6/19/2021 | | @ | SFG | W | 6-3 | | Lester,Jon | L | Bowman | | Lopez,Re | R |
| 6/20/2021 | | @ | SFG | W | 5-2 | | Giolito | R | Giolito | Fairbanks | Anderson,Ty | L |
| 6/22/2021 | | @ |  LAD | W | 10-4 | | Chatwood | R | Chatwood | | McKenzie | R |
| 6/23/2021 | | @ | LAD | L | 2-3 | | Ohtani | R | Ohtani | | Sanchez,S | R |
| 6/24/2021 | | @ | LAD | L | 3-5 | | Lester,Jon | L | Lester,Jon | | Allard | L |
| 6/25/2021 | | @ |  Col | L | 4-11 | | Giolito | R | Giolito | | Ryu | L |
| 6/26/2021 | | @ | Col | L | 0-5 | | Porcello | R | Porcello | | Greinke | R |
| 6/27/2021 | | @ | Col | L | 4-7 | | Chatwood | R | Chatwood | | Morton | R |
| 7/15/2021 | | | Bos | L | 0-2 | | Chatwood | R | Barnes,M | | Rodriguez,E | L |
| 7/15/2021 | | @ | Tex | W | 10-7 | | Giolito | R | Giolito | Diehl | Hoffman | R |
| 7/16/2021 | | | Bos | W | 7-0 | | Bassitt | R | Bassitt | | Blach | L |
| 7/16/2021 | | @ | Tex | W | 6-5 | 10 | Bassitt | R | Oberg | Rogers,Ty | Faedo | R |
| 7/17/2021 | | | Bos | W | 7-6 | | Lester,Jon | L | Hughes | Oberg | Margevicius | L |
| 7/17/2021 | | @ | Tex | W | 7-1 | | Lester,Jon | L | Lester,Jon | | Oviedo | R |
| 7/18/2021 | | | Bos | L | 3-4 | | Giolito | R | Oberg | | Romano,S | R |
| 7/18/2021 | | @ | Tex | W | 8-7 | 10 | Chatwood | R | Oberg | | Alzolay | R |
| 7/19/2021 | | | Det | W | 3-2 | 10 | Porcello | R | Rogers,Ty | | Rogers,Tr | L |
| 7/19/2021 | | @ | Min | W | 3-1 | | Porcello | R | Porcello | Bowman | Paddack | R |
| 7/20/2021 | | | Det | W | 4-2 | | Chatwood | R | Chatwood | Rogers,Ty | Salazar | R |
| 7/20/2021 | | @ | Min | W | 7-3 | | Giolito | R | Giolito | Fairbanks | Patino | R |
| 7/21/2021 | | | Det | W | 4-0 | | Bassitt | R | Bassitt | Bleier | Duffy,D | L |
| 7/21/2021 | | @ | Min | L | 4-5 | | Bassitt | R | Rogers,Ty | | Gallen | R |
| 7/23/2021 | | | Was | W | 3-0 | | Giolito | R | Giolito | Diehl | Burnes | R |
| 7/23/2021 | | @ |  Oak | W | 6-3 | | Chatwood | R | Hughes | Diehl | Quantrill | R |
| 7/24/2021 | | | Was | W | 9-1 | | Lester,Jon | L | Lester,Jon | | Kuhl | R |
| 7/24/2021 | | @ | Oak | L | 0-7 | | Porcello | R | Porcello | | Wainwright | R |
| 7/25/2021 | | | Was | L | 4-6 | | Chatwood | R | Chatwood | | Eflin | R |
| 7/25/2021 | | @ | Oak | L | 5-8 | | Giolito | R | Rogers,Ty | | Abreu,B | R |
| 7/26/2021 | | | Was | W | 6-5 | 16 | Porcello | R | Bleier | | Luzardo | L |
| 7/26/2021 | | @ | Oak | W | 6-1 | | Bassitt | R | Bassitt | | Hamels | L |
| 8/6/2021 | | | Min | W | 8-6 | | Bassitt | R | Bassitt | Diehl | Gallen | R |
| 8/6/2021 | | @ | Det | W | 7-6 | | Wood,A | L | Puk | Bowman | Perez,Ma | L |
| 8/7/2021 | | | Min | W | 8-7 | 11 | Wood,A | L | Diehl | | Urias,J | L |
| 8/7/2021 | | @ | Det | L | 1-7 | | Lester,Jon | L | Lester,Jon | | Webb,L | R |
| 8/8/2021 | | | Min | W | 7-4 | | Lester,Jon | L | Lester,Jon | Rogers,Ty | Rasmussen | R |
| 8/8/2021 | | @ | Det | L | 0-6 | | Porcello | R | Porcello | | Happ,J.A. | L |
| 8/9/2021 | | | Tor | L | 3-7 | | Giolito | R | Giolito | | Reid-Foley | R |
| 8/9/2021 | | @ | Cle | L | 2-4 | | Bassitt | R | Bassitt | | Keller, Brad | R |
| 8/10/2021 | | | Tor | W | 11-6 | | Porcello | R | Porcello | | Smyly | L |
| 8/10/2021 | | @ | Cle | L | 4-8 | | Giolito | R | Giolito | | Keller, Mitch | R |
| 8/11/2021 | | | Tor | W | 9-1 | | Bassitt | R | Bassitt | Diehl | Lambert,P | R |
| 8/11/2021 | | @ | Cle | W | 5-2 | | Wood,A | L | Wood,A | Rogers,Ty | Honeywell | R |
| 8/13/2021 | | @ |  Bal | L | 1-8 | | Lester,Jon | L | Lester,Jon | | Montgomery,J | L |
| 8/13/2021 | | |  LAA | W | 4-3 | | Lester,Jon | L | Lester,Jon | Hughes | Houck | R |
| 8/14/2021 | | @ | Bal | W | 2-1 | | Porcello | R | Hughes | Rogers,Ty | Dunning | R |
| 8/14/2021 | | | LAA | W | 8-3 | | Giolito | R | Giolito | | Akin | L |
| 8/15/2021 | | @ | Bal | W | 8-0 | | Giolito | R | Giolito | | Foltynewicz | R |
| 8/15/2021 | | | LAA | W | 6-4 | | Porcello | R | Porcello | Diehl | Harvey,H | R |
| 8/16/2021 | | @ | Bal | L | 1-2 | | Wood,A | L | Wood,A | | Teheran | R |
| 8/16/2021 | | | LAA | W | 6-1 | | Bassitt | R | Diehl | | Junis | R |
| 8/23/2021 | | | Bal | W | 9-2 | | Puk | L | Puk | | German,D | R |
| 8/23/2021 | | @ | LAA | W | 9-5 | | Puk | L | Puk | | Pineda | R |
| 8/24/2021 | | | Bal | W | 6-5 | | Lester,Jon | L | Diehl | Bowman | Bielak | R |
| 8/24/2021 | | @ | LAA | L | 4-5 | | Lester,Jon | L | Lester,Jon | | Keuchel | L |
| 8/25/2021 | | | Bal | L | 1-5 | | Wood,A | L | Wood,A | | Hill,R | L |
| 8/25/2021 | | @ | LAA | W | 9-6 | | Porcello | R | Bowman | Rogers,Ty | Williams,Tr | R |
| 8/26/2021 | | | Bal | W | 6-3 | | Porcello | R | Porcello | Rogers,Ty | Teheran | R |
| 8/26/2021 | | @ | LAA | W | 4-2 | | Wood,A | L | Wood,A | Diehl | Houck | R |
| 8/27/2021 | | | NYY | W | 7-3 | 10 | Giolito | R | Bowman | | Flaherty,J | R |
| 8/27/2021 | | @ | KCR | L | 3-4 | 10 | Giolito | R | Rogers,Ty | | Newsome | R |
| 8/28/2021 | | | NYY | W | 7-5 | | Puk | L | Rogers,Ty | Bowman | Ross,T | R |
| 8/28/2021 | | @ | KCR | L | 6-7 | | Puk | L | Fairbanks | | Antone | R |
| 8/29/2021 | | | NYY | W | 6-3 | | Lester,Jon | L | Fairbanks | Diehl | Toussaint | R |
| 8/29/2021 | | @ | KCR | W | 7-3 | 10 | Lester,Jon | L | Rogers,Ty | Chatwood | Hudson,Dak | R |
| 8/30/2021 | | | NYY | W | 5-4 | | Wood,A | L | Bowman | | Alexander,TyJo | L |
| 8/30/2021 | | @ | KCR | W | 9-1 | | Porcello | R | Porcello | | Davies | R |
| 9/7/2021 | | @ | Tor | W | 7-2 | | Ohtani | R | Ohtani | | Freeland | L |
| 9/7/2021 | | | Cle | W | 5-4 | | Porcello | R | Diehl | | Sulser,C | R |
| 9/8/2021 | | @ | Tor | W | 8-1 | | Giolito | R | Giolito | | Lambert,P | R |
| 9/8/2021 | | | Cle | L | 1-3 | | Lester,Jon | L | Lester,Jon | | Keller, Brad | R |
| 9/9/2021 | | @ | Tor | W | 12-7 | | Bassitt | R | Bassitt | | Yamaguchi | R |
| 9/9/2021 | | | Cle | W | 14-0 | | Ohtani | R | Ohtani | | Hendricks | R |
| 9/10/2021 | | @ | Mtl | L | 3-5 | | Porcello | R | Porcello | | Thorpe | L |
| 9/10/2021 | | | Oak | L | 4-6 | | Wood,A | L | Wood,A | | Cotton | R |
| 9/11/2021 | | @ | Mtl | L | 2-6 | | Puk | L | Puk | | Anderson,Bre | L |
| 9/11/2021 | | | Oak | L | 5-6 | | Bassitt | R | Bassitt | | Quantrill | R |
| 9/12/2021 | | @ | Mtl | W | 8-4 | | Ohtani | R | Ohtani | | Lopez,P | R |
| 9/12/2021 | | | Oak | L | 2-4 | | Porcello | R | Porcello | | Hamels | L |
| 9/13/2021 | | @ | Mtl | W | 3-1 | | Giolito | R | Giolito | | Bumgarner | L |
| 9/13/2021 | | | Oak | L | 1-6 | | Lester,Jon | L | Lester,Jon | | Cole,G | R |
| 9/24/2021 | | | Det | W | 4-2 | | Ohtani | R | Ohtani | Bowman | Webb,L | R |
| 9/24/2021 | | @ | Min | L | 4-5 | | Lester,Jon | L | Barnes,M | | Gallen | R |
| 9/25/2021 | | | Det | L | 2-3 | 10 | Bassitt | R | Rogers,Ty | | Duffy,D | L |
| 9/25/2021 | | @ | Min | W | 4-1 | | Puk | L | Puk | Bleier | Ray,R | L |
| 9/26/2021 | | | Det | W | 10-3 | | Wood,A | L | Wood,A | | Happ,J.A. | L |
| 9/26/2021 | | @ | Min | W | 5-1 | | Wood,A | L | Wood,A | | Turnbull | R |
| 9/27/2021 | | | Tor | L | 8-11 | | Giolito | R | Giolito | | Supak | R |
| 9/27/2021 | | @ | Det | L | 3-4 | | Giolito | R | Diehl | | Sheffield,Ju | L |
| 9/28/2021 | | | Tor | W | 3-2 | | Porcello | R | Rogers,Ty | Oberg | Plutko | R |
| 9/28/2021 | | @ | Det | L | 5-6 | | Bassitt | R | Rogers,Ty | | Rogers,Tr | L |
| Other |
| Game information | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | | W | L | Pct | L10 | Strk | Gm# |
| 4/8/2021 | | | Mtl | L | | 9 | 13 | | 0 | 1 | .000 | 0-1 | L1 | 1 |
| 4/8/2021 | | @ | Sea | W | Turner,J | 4 | 2 | | 1 | 1 | .500 | 1-1 | W1 | 2 |
| 4/9/2021 | | | Mtl | L | | 2 | 3 | | 1 | 2 | .333 | 1-2 | L1 | 3 |
| 4/9/2021 | | @ | Sea | W | Castellanos,N | 4 | 2 | | 2 | 2 | .500 | 2-2 | W1 | 4 |
| 4/10/2021 | | | Mtl | W | Fisher | 4 | 2 | | 3 | 2 | .600 | 3-2 | W2 | 5 |
| 4/10/2021 | | @ | Sea | L | | 4 | 5 | | 3 | 3 | .500 | 3-3 | L1 | 6 |
| 4/11/2021 | | | Mtl | W | Castellanos,N | 10 | 2 | | 4 | 3 | .571 | 4-3 | W1 | 7 |
| 4/11/2021 | | @ | Sea | L | | 1 | 5 | | 4 | 4 | .500 | 4-4 | L1 | 8 |
| 4/12/2021 | | | Tor | L | | 6 | 8 | | 4 | 5 | .444 | 4-5 | L2 | 9 |
| 4/12/2021 | | @ | Cle | L | | 5 | 6 | | 4 | 6 | .400 | 4-6 | L3 | 10 |
| 4/13/2021 | | | Tor | L | | 3 | 7 | | 4 | 7 | .364 | 4-6 | L4 | 11 |
| 4/13/2021 | | @ | Cle | L | | 3 | 5 | | 4 | 8 | .333 | 3-7 | L5 | 12 |
| 4/14/2021 | | | Tor | W | Fisher | 6 | 2 | | 5 | 8 | .385 | 4-6 | W1 | 13 |
| 4/14/2021 | | @ | Cle | W | | 4 | 3 | | 6 | 8 | .429 | 4-6 | W2 | 14 |
| 4/16/2021 | | | Min | L | | 1 | 3 | | 6 | 9 | .400 | 3-7 | L1 | 15 |
| 4/16/2021 | | @ | Det | L | | 0 | 9 | | 6 | 10 | .375 | 3-7 | L2 | 16 |
| 4/17/2021 | | | Min | L | | 2 | 5 | | 6 | 11 | .353 | 2-8 | L3 | 17 |
| 4/17/2021 | | @ | Det | W | Albies | 3 | 1 | | 7 | 11 | .389 | 3-7 | W1 | 18 |
| 4/18/2021 | | | Min | W | Diaz,L | 3 | 1 | | 8 | 11 | .421 | 4-6 | W2 | 19 |
| 4/18/2021 | | @ | Det | L | | 3 | 4 | | 8 | 12 | .400 | 4-6 | L1 | 20 |
| 4/23/2021 | | | Phi | W | Hedges | 4 | 1 | | 9 | 12 | .429 | 5-5 | W1 | 21 |
| 4/24/2021 | | | Phi | W | Jimenez,El | 7 | 4 | | 10 | 12 | .455 | 6-4 | W2 | 22 |
| 4/25/2021 | | | Phi | L | | 1 | 4 | | 10 | 13 | .435 | 5-5 | L1 | 23 |
| 4/27/2021 | | | Pit | L | | 3 | 5 | | 10 | 14 | .417 | 4-6 | L2 | 24 |
| 4/28/2021 | | | Pit | L | | 3 | 12 | | 10 | 15 | .400 | 4-6 | L3 | 25 |
| 4/29/2021 | | | Pit | L | | 0 | 1 | | 10 | 16 | .385 | 4-6 | L4 | 26 |
| 5/3/2021 | | @ | NYY | W | Bruce | 3 | 2 | | 11 | 16 | .407 | 5-5 | W1 | 27 |
| 5/3/2021 | | | Tex | W | Fisher | 6 | 2 | | 12 | 16 | .429 | 5-5 | W2 | 28 |
| 5/4/2021 | | @ | NYY | W | Albies | 4 | 0 | | 13 | 16 | .448 | 5-5 | W3 | 29 |
| 5/4/2021 | | | Tex | W | Bruce | 6 | 4 | | 14 | 16 | .467 | 6-4 | W4 | 30 |
| 5/5/2021 | | @ | NYY | L | | 3 | 6 | | 14 | 17 | .452 | 5-5 | L1 | 31 |
| 5/5/2021 | | | Tex | L | | 4 | 9 | | 14 | 18 | .438 | 4-6 | L2 | 32 |
| 5/6/2021 | | @ | NYY | L | | 2 | 5 | | 14 | 19 | .424 | 4-6 | L3 | 33 |
| 5/6/2021 | | | Tex | W | Jimenez,El | 10 | 2 | | 15 | 19 | .441 | 5-5 | W1 | 34 |
| 5/7/2021 | | @ | Ari | L | | 2 | 3 | | 15 | 20 | .429 | 5-5 | L1 | 35 |
| 5/8/2021 | | @ | Ari | L | | 0 | 5 | | 15 | 21 | .417 | 5-5 | L2 | 36 |
| 5/9/2021 | | @ | Ari | W | Jimenez,El | 6 | 5 | | 16 | 21 | .432 | 5-5 | W1 | 37 |
| 5/11/2021 | | @ | SDP | W | Simmons | 6 | 5 | | 17 | 21 | .447 | 5-5 | W2 | 38 |
| 5/12/2021 | | @ | SDP | L | | 3 | 4 | | 17 | 22 | .436 | 4-6 | L1 | 39 |
| 5/13/2021 | | @ | SDP | W | Turner,J | 9 | 3 | | 18 | 22 | .450 | 4-6 | W1 | 40 |
| 5/24/2021 | | @ | Bos | W | Harper,B | 10 | 6 | | 19 | 22 | .463 | 5-5 | W2 | 41 |
| 5/24/2021 | | | KCR | L | | 4 | 5 | | 19 | 23 | .452 | 5-5 | L1 | 42 |
| 5/25/2021 | | @ | Bos | W | Vargas,I | 6 | 2 | | 20 | 23 | .465 | 6-4 | W1 | 43 |
| 5/25/2021 | | | KCR | W | Jimenez,El | 8 | 3 | | 21 | 23 | .477 | 6-4 | W2 | 44 |
| 5/26/2021 | | @ | Bos | L | | 2 | 3 | | 21 | 24 | .467 | 6-4 | L1 | 45 |
| 5/26/2021 | | | KCR | L | | 2 | 5 | | 21 | 25 | .457 | 6-4 | L2 | 46 |
| 5/27/2021 | | @ | Bos | W | Bart | 9 | 5 | | 22 | 25 | .468 | 6-4 | W1 | 47 |
| 5/27/2021 | | | KCR | W | Hedges | 4 | 2 | | 23 | 25 | .479 | 6-4 | W2 | 48 |
| 5/28/2021 | | @ | Tor | L | | 8 | 13 | | 23 | 26 | .469 | 6-4 | L1 | 49 |
| 5/28/2021 | | | Cle | W | Simmons | 4 | 3 | | 24 | 26 | .480 | 6-4 | W1 | 50 |
| 5/29/2021 | | @ | Tor | L | | 5 | 20 | | 24 | 27 | .471 | 5-5 | L1 | 51 |
| 5/29/2021 | | | Cle | L | | 2 | 3 | | 24 | 28 | .462 | 5-5 | L2 | 52 |
| 5/30/2021 | | @ | Tor | W | Harper,B | 4 | 2 | | 25 | 28 | .472 | 5-5 | W1 | 53 |
| 5/30/2021 | | | Cle | L | | 1 | 10 | | 25 | 29 | .463 | 4-6 | L1 | 54 |
| 6/1/2021 | | | Sea | L | | 4 | 7 | | 25 | 30 | .455 | 4-6 | L2 | 55 |
| 6/1/2021 | | @ | Was | W | Ohtani | 6 | 5 | | 26 | 30 | .464 | 5-5 | W1 | 56 |
| 6/2/2021 | | | Sea | L | | 5 | 6 | | 26 | 31 | .456 | 4-6 | L1 | 57 |
| 6/2/2021 | | @ | Was | L | | 1 | 7 | | 26 | 32 | .448 | 3-7 | L2 | 58 |
| 6/3/2021 | | | Sea | W | Diaz,L | 9 | 3 | | 27 | 32 | .458 | 4-6 | W1 | 59 |
| 6/3/2021 | | @ | Was | L | | 2 | 6 | | 27 | 33 | .450 | 3-7 | L1 | 60 |
| 6/4/2021 | | | Sea | W | Jimenez,El | 9 | 3 | | 28 | 33 | .459 | 4-6 | W1 | 61 |
| 6/4/2021 | | @ | Was | W | Castellanos,N | 6 | 4 | | 29 | 33 | .468 | 5-5 | W2 | 62 |
| 6/8/2021 | | | NYM | L | | 7 | 15 | | 29 | 34 | .460 | 4-6 | L1 | 63 |
| 6/9/2021 | | | NYM | L | | 4 | 10 | | 29 | 35 | .453 | 4-6 | L2 | 64 |
| 6/10/2021 | | | NYM | L | | 1 | 4 | | 29 | 36 | .446 | 4-6 | L3 | 65 |
| 6/11/2021 | | | Atl | W | Ohtani | 14 | 2 | | 30 | 36 | .455 | 4-6 | W1 | 66 |
| 6/12/2021 | | | Atl | W | Diaz,L | 10 | 9 | | 31 | 36 | .463 | 5-5 | W2 | 67 |
| 6/13/2021 | | | Atl | L | | 2 | 6 | | 31 | 37 | .456 | 5-5 | L1 | 68 |
| 6/15/2021 | | | Mia | L | | 5 | 8 | | 31 | 38 | .449 | 4-6 | L2 | 69 |
| 6/16/2021 | | | Mia | L | | 1 | 2 | | 31 | 39 | .443 | 4-6 | L3 | 70 |
| 6/17/2021 | | | Mia | W | Simmons | 5 | 3 | | 32 | 39 | .451 | 4-6 | W1 | 71 |
| 6/18/2021 | | @ | SFG | L | | 1 | 3 | | 32 | 40 | .444 | 3-7 | L1 | 72 |
| 6/19/2021 | | @ | SFG | W | Hedges | 6 | 3 | | 33 | 40 | .452 | 4-6 | W1 | 73 |
| 6/20/2021 | | @ | SFG | W | | 5 | 2 | | 34 | 40 | .459 | 5-5 | W2 | 74 |
| 6/22/2021 | | @ | LAD | W | Diaz,L | 10 | 4 | | 35 | 40 | .467 | 6-4 | W3 | 75 |
| 6/23/2021 | | @ | LAD | L | | 2 | 3 | | 35 | 41 | .461 | 5-5 | L1 | 76 |
| 6/24/2021 | | @ | LAD | L | | 3 | 5 | | 35 | 42 | .455 | 4-6 | L2 | 77 |
| 6/25/2021 | | @ | Col | L | | 4 | 11 | | 35 | 43 | .449 | 4-6 | L3 | 78 |
| 6/26/2021 | | @ | Col | L | | 0 | 5 | | 35 | 44 | .443 | 4-6 | L4 | 79 |
| 6/27/2021 | | @ | Col | L | | 4 | 7 | | 35 | 45 | .438 | 4-6 | L5 | 80 |
| 7/15/2021 | | | Bos | L | | 0 | 2 | | 35 | 46 | .432 | 3-7 | L6 | 81 |
| 7/15/2021 | | @ | Tex | W | Bart | 10 | 7 | | 36 | 46 | .439 | 4-6 | W1 | 82 |
| 7/16/2021 | | | Bos | W | Albies | 7 | 0 | | 37 | 46 | .446 | 4-6 | W2 | 83 |
| 7/16/2021 | | @ | Tex | W | | 6 | 5 | | 38 | 46 | .452 | 4-6 | W3 | 84 |
| 7/17/2021 | | | Bos | W | Albies | 7 | 6 | | 39 | 46 | .459 | 4-6 | W4 | 85 |
| 7/17/2021 | | @ | Tex | W | Diaz,L | 7 | 1 | | 40 | 46 | .465 | 5-5 | W5 | 86 |
| 7/18/2021 | | | Bos | L | | 3 | 4 | | 40 | 47 | .460 | 5-5 | L1 | 87 |
| 7/18/2021 | | @ | Tex | W | Jimenez,El | 8 | 7 | | 41 | 47 | .466 | 6-4 | W1 | 88 |
| 7/19/2021 | | | Det | W | Vargas,I | 3 | 2 | | 42 | 47 | .472 | 7-3 | W2 | 89 |
| 7/19/2021 | | @ | Min | W | Jimenez,El | 3 | 1 | | 43 | 47 | .478 | 8-2 | W3 | 90 |
| 7/20/2021 | | | Det | W | Bart | 4 | 2 | | 44 | 47 | .484 | 9-1 | W4 | 91 |
| 7/20/2021 | | @ | Min | W | Bart | 7 | 3 | | 45 | 47 | .489 | 9-1 | W5 | 92 |
| 7/21/2021 | | | Det | W | Albies | 4 | 0 | | 46 | 47 | .495 | 9-1 | W6 | 93 |
| 7/21/2021 | | @ | Min | L | | 4 | 5 | | 46 | 48 | .489 | 8-2 | L1 | 94 |
| 7/23/2021 | | | Was | W | Jimenez,El | 3 | 0 | | 47 | 48 | .495 | 8-2 | W1 | 95 |
| 7/23/2021 | | @ | Oak | W | Albies | 6 | 3 | | 48 | 48 | .500 | 8-2 | W2 | 96 |
| 7/24/2021 | | | Was | W | | 9 | 1 | | 49 | 48 | .505 | 9-1 | W3 | 97 |
| 7/24/2021 | | @ | Oak | L | | 0 | 7 | | 49 | 49 | .500 | 8-2 | L1 | 98 |
| 7/25/2021 | | | Was | L | | 4 | 6 | | 49 | 50 | .495 | 7-3 | L2 | 99 |
| 7/25/2021 | | @ | Oak | L | | 5 | 8 | | 49 | 51 | .490 | 6-4 | L3 | 100 |
| 7/26/2021 | | | Was | W | Simmons | 6 | 5 | | 50 | 51 | .495 | 6-4 | W1 | 101 |
| 7/26/2021 | | @ | Oak | W | Jimenez,El | 6 | 1 | | 51 | 51 | .500 | 6-4 | W2 | 102 |
| 8/6/2021 | | | Min | W | Harper,B | 8 | 6 | | 52 | 51 | .505 | 6-4 | W3 | 103 |
| 8/6/2021 | | @ | Det | W | Fisher | 7 | 6 | | 53 | 51 | .510 | 7-3 | W4 | 104 |
| 8/7/2021 | | | Min | W | Jimenez,El | 8 | 7 | | 54 | 51 | .514 | 7-3 | W5 | 105 |
| 8/7/2021 | | @ | Det | L | | 1 | 7 | | 54 | 52 | .509 | 6-4 | L1 | 106 |
| 8/8/2021 | | | Min | W | Harper,B | 7 | 4 | | 55 | 52 | .514 | 6-4 | W1 | 107 |
| 8/8/2021 | | @ | Det | L | | 0 | 6 | | 55 | 53 | .509 | 6-4 | L1 | 108 |
| 8/9/2021 | | | Tor | L | | 3 | 7 | | 55 | 54 | .505 | 6-4 | L2 | 109 |
| 8/9/2021 | | @ | Cle | L | | 2 | 4 | | 55 | 55 | .500 | 6-4 | L3 | 110 |
| 8/10/2021 | | | Tor | W | Bart | 11 | 6 | | 56 | 55 | .505 | 6-4 | W1 | 111 |
| 8/10/2021 | | @ | Cle | L | | 4 | 8 | | 56 | 56 | .500 | 5-5 | L1 | 112 |
| 8/11/2021 | | | Tor | W | Bruce | 9 | 1 | | 57 | 56 | .504 | 5-5 | W1 | 113 |
| 8/11/2021 | | @ | Cle | W | Ohtani | 5 | 2 | | 58 | 56 | .509 | 5-5 | W2 | 114 |
| 8/13/2021 | | @ | Bal | L | | 1 | 8 | | 58 | 57 | .504 | 4-6 | L1 | 115 |
| 8/13/2021 | | | LAA | W | Albies | 4 | 3 | | 59 | 57 | .509 | 5-5 | W1 | 116 |
| 8/14/2021 | | @ | Bal | W | Ohtani | 2 | 1 | | 60 | 57 | .513 | 5-5 | W2 | 117 |
| 8/14/2021 | | | LAA | W | Castellanos,N | 8 | 3 | | 61 | 57 | .517 | 6-4 | W3 | 118 |
| 8/15/2021 | | @ | Bal | W | Ohtani | 8 | 0 | | 62 | 57 | .521 | 7-3 | W4 | 119 |
| 8/15/2021 | | | LAA | W | Bruce | 6 | 4 | | 63 | 57 | .525 | 8-2 | W5 | 120 |
| 8/16/2021 | | @ | Bal | L | | 1 | 2 | | 63 | 58 | .521 | 7-3 | L1 | 121 |
| 8/16/2021 | | | LAA | W | Castellanos,N | 6 | 1 | | 64 | 58 | .525 | 8-2 | W1 | 122 |
| 8/23/2021 | | | Bal | W | Bruce | 9 | 2 | | 65 | 58 | .528 | 8-2 | W2 | 123 |
| 8/23/2021 | | @ | LAA | W | Harper,B | 9 | 5 | | 66 | 58 | .532 | 8-2 | W3 | 124 |
| 8/24/2021 | | | Bal | W | Harper,B | 6 | 5 | | 67 | 58 | .536 | 9-1 | W4 | 125 |
| 8/24/2021 | | @ | LAA | L | | 4 | 5 | | 67 | 59 | .532 | 8-2 | L1 | 126 |
| 8/25/2021 | | | Bal | L | | 1 | 5 | | 67 | 60 | .528 | 7-3 | L2 | 127 |
| 8/25/2021 | | @ | LAA | W | Fisher | 9 | 6 | | 68 | 60 | .531 | 7-3 | W1 | 128 |
| 8/26/2021 | | | Bal | W | Ohtani | 6 | 3 | | 69 | 60 | .535 | 7-3 | W2 | 129 |
| 8/26/2021 | | @ | LAA | W | Vargas,I | 4 | 2 | | 70 | 60 | .538 | 7-3 | W3 | 130 |
| 8/27/2021 | | | NYY | W | Harper,B | 7 | 3 | | 71 | 60 | .542 | 8-2 | W4 | 131 |
| 8/27/2021 | | @ | KCR | L | | 3 | 4 | | 71 | 61 | .538 | 7-3 | L1 | 132 |
| 8/28/2021 | | | NYY | W | Turner,J | 7 | 5 | | 72 | 61 | .541 | 7-3 | W1 | 133 |
| 8/28/2021 | | @ | KCR | L | | 6 | 7 | | 72 | 62 | .537 | 6-4 | L1 | 134 |
| 8/29/2021 | | | NYY | W | Turner,J | 6 | 3 | | 73 | 62 | .541 | 6-4 | W1 | 135 |
| 8/29/2021 | | @ | KCR | W | Albies | 7 | 3 | | 74 | 62 | .544 | 7-3 | W2 | 136 |
| 8/30/2021 | | | NYY | W | Diaz,L | 5 | 4 | | 75 | 62 | .547 | 8-2 | W3 | 137 |
| 8/30/2021 | | @ | KCR | W | Harper,B | 9 | 1 | | 76 | 62 | .551 | 8-2 | W4 | 138 |
| 9/7/2021 | | @ | Tor | W | Simmons | 7 | 2 | | 77 | 62 | .554 | 8-2 | W5 | 139 |
| 9/7/2021 | | | Cle | W | | 5 | 4 | | 78 | 62 | .557 | 8-2 | W6 | 140 |
| 9/8/2021 | | @ | Tor | W | Harper,B | 8 | 1 | | 79 | 62 | .560 | 8-2 | W7 | 141 |
| 9/8/2021 | | | Cle | L | | 1 | 3 | | 79 | 63 | .556 | 8-2 | L1 | 142 |
| 9/9/2021 | | @ | Tor | W | Bruce | 12 | 7 | | 80 | 63 | .559 | 8-2 | W1 | 143 |
| 9/9/2021 | | | Cle | W | | 14 | 0 | | 81 | 63 | .563 | 9-1 | W2 | 144 |
| 9/10/2021 | | @ | Mtl | L | | 3 | 5 | | 81 | 64 | .559 | 8-2 | L1 | 145 |
| 9/10/2021 | | | Oak | L | | 4 | 6 | | 81 | 65 | .555 | 7-3 | L2 | 146 |
| 9/11/2021 | | @ | Mtl | L | | 2 | 6 | | 81 | 66 | .551 | 6-4 | L3 | 147 |
| 9/11/2021 | | | Oak | L | | 5 | 6 | | 81 | 67 | .547 | 5-5 | L4 | 148 |
| 9/12/2021 | | @ | Mtl | W | Turner,J | 8 | 4 | | 82 | 67 | .550 | 5-5 | W1 | 149 |
| 9/12/2021 | | | Oak | L | | 2 | 4 | | 82 | 68 | .547 | 4-6 | L1 | 150 |
| 9/13/2021 | | @ | Mtl | W | Vargas,I | 3 | 1 | | 83 | 68 | .550 | 4-6 | W1 | 151 |
| 9/13/2021 | | | Oak | L | | 1 | 6 | | 83 | 69 | .546 | 4-6 | L1 | 152 |
| 9/24/2021 | | | Det | W | Jimenez,El | 4 | 2 | | 84 | 69 | .549 | 4-6 | W1 | 153 |
| 9/24/2021 | | @ | Min | L | | 4 | 5 | | 84 | 70 | .545 | 3-7 | L1 | 154 |
| 9/25/2021 | | | Det | L | | 2 | 3 | | 84 | 71 | .542 | 3-7 | L2 | 155 |
| 9/25/2021 | | @ | Min | W | Bart | 4 | 1 | | 85 | 71 | .545 | 4-6 | W1 | 156 |
| 9/26/2021 | | | Det | W | Castellanos,N | 10 | 3 | | 86 | 71 | .548 | 5-5 | W2 | 157 |
| 9/26/2021 | | @ | Min | W | Ohtani | 5 | 1 | | 87 | 71 | .551 | 6-4 | W3 | 158 |
| 9/27/2021 | | | Tor | L | | 8 | 11 | | 87 | 72 | .547 | 5-5 | L1 | 159 |
| 9/27/2021 | | @ | Det | L | | 3 | 4 | | 87 | 73 | .544 | 5-5 | L2 | 160 |
| 9/28/2021 | | | Tor | W | Harper,B | 3 | 2 | | 88 | 73 | .547 | 5-5 | W1 | 161 |
| 9/28/2021 | | @ | Det | L | | 5 | 6 | | 88 | 74 | .543 | 5-5 | L1 | 162 |