Team game results -- 2021 Toronto Blue Jays
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | Decision | Save | Versus | T |
| 4/8/2021 | | |  Bos | L | 2-3 | 11 | Yamaguchi | R | Osuna,R | | Rodriguez,E | L |
| 4/8/2021 | | @ |  Oak | L | 1-4 | | Yamaguchi | R | Yamaguchi | | Cole,G | R |
| 4/9/2021 | | | Bos | L | 0-3 | | Smyly | L | Smyly | | Smeltzer | L |
| 4/9/2021 | | @ | Oak | L | 6-7 | 11 | Smyly | L | Romano,J | | Hamels | L |
| 4/10/2021 | | | Bos | W | 4-0 | | Freeland | L | Freeland | Biagini | Margevicius | L |
| 4/10/2021 | | @ | Oak | L | 3-5 | | Freeland | L | Freeland | | Wainwright | R |
| 4/11/2021 | | | Bos | W | 6-2 | | Reid-Foley | R | Romano,J | | Clarke | R |
| 4/11/2021 | | @ | Oak | W | 8-1 | | Reid-Foley | R | Romano,J | | Walker,T | R |
| 4/12/2021 | | |  Min | L | 7-13 | | Sharp | R | Sharp | | Perez,Ci | L |
| 4/12/2021 | | @ |  ChW | W | 8-6 | | Sharp | R | Sharp | Osuna,R | Porcello | R |
| 4/13/2021 | | | Min | W | 8-6 | 12 | Yamaguchi | R | Buttrey | | Paddack | R |
| 4/13/2021 | | @ | ChW | W | 7-3 | | Yamaguchi | R | Yamaguchi | | Puk | L |
| 4/14/2021 | | | Min | L | 2-12 | | Smyly | L | Smyly | | Lauer | L |
| 4/14/2021 | | @ | ChW | L | 2-6 | | Smyly | L | Smyly | | Ohtani | R |
| 4/16/2021 | | |  Det | L | 3-9 | | Freeland | L | Freeland | | Fulmer,M | R |
| 4/16/2021 | | @ |  Cle | L | 0-4 | | Freeland | L | Freeland | | Keller, Brad | R |
| 4/17/2021 | | | Det | W | 3-2 | 10 | Reid-Foley | R | Osuna,R | | Sheffield,Ju | L |
| 4/17/2021 | | @ | Cle | L | 2-6 | | Reid-Foley | R | Reid-Foley | | Keller, Mitch | R |
| 4/18/2021 | | | Det | W | 6-1 | | Yamaguchi | R | Yamaguchi | | Happ,J.A. | L |
| 4/18/2021 | | @ | Cle | L | 3-8 | | Yamaguchi | R | Yamaguchi | | Verlander | R |
| 4/23/2021 | | |  Pit | W | 9-7 | | Smyly | L | Cabrera,G | Osuna,R | Senzatela | R |
| 4/24/2021 | | | Pit | W | 7-3 | | Freeland | L | Freeland | | Valdez,F | L |
| 4/25/2021 | | | Pit | W | 7-6 | | Reid-Foley | R | Reid-Foley | Osuna,R | Plesac | R |
| 4/27/2021 | | |  Atl | W | 2-1 | | Yamaguchi | R | Fry,J | Osuna,R | Soroka | R |
| 4/28/2021 | | | Atl | L | 2-4 | | Merryweather | R | Merryweather | | Singer,B | R |
| 4/29/2021 | | | Atl | W | 5-2 | | Smyly | L | Smyly | Osuna,R | Santana,Er | R |
| 5/3/2021 | | @ |  Mtl | W | 4-3 | 11 | Smyly | L | Buttrey | Fry,J | Anderson,Bre | L |
| 5/3/2021 | | |  Sea | W | 8-3 | | Smyly | L | Smyly | | Odorizzi | R |
| 5/4/2021 | | @ | Mtl | W | 6-3 | | Freeland | L | Biagini | Cabrera,G | Blackburn | R |
| 5/4/2021 | | | Sea | L | 5-9 | | Freeland | L | Freeland | | Gonzales | L |
| 5/5/2021 | | @ | Mtl | W | 10-4 | | Reid-Foley | R | Reid-Foley | | Richards,T | R |
| 5/5/2021 | | | Sea | W | 8-4 | | Reid-Foley | R | Reid-Foley | | Samardzija | R |
| 5/6/2021 | | @ | Mtl | W | 4-3 | 11 | Yamaguchi | R | Buttrey | | Garcia,Ri | R |
| 5/6/2021 | | | Sea | W | 5-4 | | Yamaguchi | R | Yamaguchi | Osuna,R | Paxton | L |
| 5/7/2021 | | @ |  Col | L | 4-7 | | Freeland | L | Romano,J | | Greinke | R |
| 5/8/2021 | | @ | Col | L | 4-5 | | Smyly | L | Fry,J | | Morton | R |
| 5/9/2021 | | @ | Col | L | 3-11 | | Reid-Foley | R | Reid-Foley | | Montas | R |
| 5/11/2021 | | @ |  SFG | L | 1-2 | | Yamaguchi | R | Yamaguchi | | Lopez,Re | R |
| 5/12/2021 | | @ | SFG | L | 5-6 | | Merryweather | R | Osuna,R | | Urquidy | R |
| 5/13/2021 | | @ | SFG | W | 7-5 | 10 | Smyly | L | Cabrera,G | Biagini | Crowe | R |
| 5/24/2021 | | @ |  Bal | L | 3-4 | | Yamaguchi | R | Buttrey | | German,D | R |
| 5/24/2021 | | |  Tex | L | 5-7 | | Freeland | L | Freeland | | Agrazal | R |
| 5/25/2021 | | @ | Bal | L | 2-3 | | Reid-Foley | R | Reid-Foley | | Foltynewicz | R |
| 5/25/2021 | | | Tex | W | 12-4 | | Reid-Foley | R | Fry,J | | King | R |
| 5/26/2021 | | @ | Bal | W | 6-0 | | Freeland | L | Freeland | | Hill,R | L |
| 5/26/2021 | | | Tex | L | 3-5 | | Yamaguchi | R | Yamaguchi | | Matz | L |
| 5/27/2021 | | @ | Bal | W | 10-9 | 10 | Plutko | R | Osuna,R | Biagini | Teheran | R |
| 5/27/2021 | | | Tex | W | 9-5 | | Plutko | R | Plutko | | Gomber | L |
| 5/28/2021 | | | ChW | W | 13-8 | | Lambert,P | R | Cabrera,G | | Giolito | R |
| 5/28/2021 | | @ | Min | W | 11-2 | | Lambert,P | R | Lambert,P | | Perez,Ci | L |
| 5/29/2021 | | | ChW | W | 20-5 | | Freeland | L | Fry,J | | Chatwood | R |
| 5/29/2021 | | @ | Min | W | 7-4 | | Yamaguchi | R | Yamaguchi | Buttrey | Lauer | L |
| 5/30/2021 | | | ChW | L | 2-4 | | Reid-Foley | R | Biagini | | Porcello | R |
| 5/30/2021 | | @ | Min | L | 1-5 | | Reid-Foley | R | Reid-Foley | | Gallen | R |
| 6/1/2021 | | @ |  NYY | L | 2-3 | | Freeland | L | Osuna,R | | Flaherty,J | R |
| 6/1/2021 | | | Oak | L | 2-4 | | Yamaguchi | R | Yamaguchi | | Walker,T | R |
| 6/2/2021 | | @ | NYY | L | 2-3 | 10 | Plutko | R | Fry,J | | Bundy | R |
| 6/2/2021 | | | Oak | W | 3-1 | | Plutko | R | Plutko | Osuna,R | Eickhoff | R |
| 6/3/2021 | | @ | NYY | L | 1-3 | | Lambert,P | R | Lambert,P | | Javier | R |
| 6/3/2021 | | | Oak | W | 3-2 | | Lambert,P | R | Lambert,P | Osuna,R | Quantrill | R |
| 6/4/2021 | | @ | NYY | W | 2-0 | | Freeland | L | Cabrera,G | Buttrey | Minor | L |
| 6/4/2021 | | | Oak | L | 1-2 | | Freeland | L | Freeland | | Cole,G | R |
| 6/8/2021 | | |  Phi | W | 4-2 | | Reid-Foley | R | Cabrera,G | Fry,J | Jefferies | R |
| 6/9/2021 | | | Phi | L | 1-6 | | Yamaguchi | R | Yamaguchi | | Chirinos,Y | R |
| 6/10/2021 | | | Phi | L | 3-6 | | Plutko | R | Buttrey | | Sims,L | R |
| 6/11/2021 | | |  Mia | L | 1-3 | | Freeland | L | Freeland | | Weaver | R |
| 6/12/2021 | | | Mia | W | 13-3 | | Smyly | L | Smyly | | Wright,K | R |
| 6/13/2021 | | | Mia | L | 0-1 | | Reid-Foley | R | Osuna,R | | Manning | R |
| 6/15/2021 | | |  NYM | L | 2-4 | | Yamaguchi | R | Yamaguchi | | Gausman | R |
| 6/16/2021 | | | NYM | L | 4-7 | | Plutko | R | Plutko | | Cueto | R |
| 6/17/2021 | | | NYM | W | 3-2 | | Freeland | L | Freeland | Osuna,R | Means | L |
| 6/18/2021 | | @ |  Ari | L | 2-6 | | Reid-Foley | R | Reid-Foley | | Mahle | R |
| 6/19/2021 | | @ | Ari | W | 2-1 | | Yamaguchi | R | Yamaguchi | Buttrey | Canning | R |
| 6/20/2021 | | @ | Ari | L | 4-5 | | Plutko | R | Romano,J | | Strasburg | R |
| 6/22/2021 | | @ |  SDP | W | 6-0 | | Freeland | L | Freeland | | Sanchez,Aa | R |
| 6/23/2021 | | @ | SDP | W | 8-7 | | Smyly | L | Smyly | Cabrera,G | Mengden | R |
| 6/24/2021 | | @ | SDP | L | 0-3 | | Reid-Foley | R | Reid-Foley | | Maeda | R |
| 6/25/2021 | | @ |  LAD | W | 5-4 | | Yamaguchi | R | Yamaguchi | Osuna,R | Berrios | R |
| 6/26/2021 | | @ | LAD | L | 2-10 | | Plutko | R | Plutko | | Musgrove | R |
| 6/27/2021 | | @ | LAD | W | 9-3 | | Freeland | L | Freeland | | McKenzie | R |
| 7/15/2021 | | | Bal | L | 2-9 | | Lambert,P | R | Lambert,P | | Bielak | R |
| 7/15/2021 | | @ | Sea | L | 2-9 | | Smyly | L | Smyly | | Dunn,J | R |
| 7/16/2021 | | | Bal | W | 9-7 | | Supak | R | Buttrey | Osuna,R | Montgomery,J | L |
| 7/16/2021 | | @ | Sea | L | 5-8 | | Reid-Foley | R | Reid-Foley | | Odorizzi | R |
| 7/17/2021 | | | Bal | W | 9-3 | | Reid-Foley | R | Reid-Foley | | Teheran | R |
| 7/17/2021 | | @ | Sea | L | 4-7 | | Supak | R | Supak | | Leake | R |
| 7/18/2021 | | | Bal | L | 2-10 | | Smyly | L | Smyly | | Roark | R |
| 7/18/2021 | | @ | Sea | L | 1-2 | | Freeland | L | Freeland | | Samardzija | R |
| 7/19/2021 | | | Cle | L | 8-13 | | Freeland | L | Buttrey | | Woodruff | R |
| 7/19/2021 | | @ | Det | L | 5-10 | | Lambert,P | R | Lambert,P | | Rogers,Tr | L |
| 7/20/2021 | | | Cle | W | 6-3 | | Lambert,P | R | Lambert,P | Osuna,R | Honeywell | R |
| 7/20/2021 | | @ | Det | L | 6-8 | | Smyly | L | Cabrera,G | | Salazar | R |
| 7/21/2021 | | | Cle | L | 2-4 | | Supak | R | Supak | | Hendricks | R |
| 7/21/2021 | | @ | Det | W | 8-4 | 15 | Reid-Foley | R | Romano,J | | Duffy,D | L |
| 7/23/2021 | | | NYY | W | 14-12 | | Smyly | L | Smyly | Osuna,R | Bundy | R |
| 7/23/2021 | | @ |  LAA | L | 1-3 | | Supak | R | Supak | | Holmes,C | R |
| 7/24/2021 | | | NYY | W | 4-2 | | Reid-Foley | R | Biagini | Osuna,R | Lamet | R |
| 7/24/2021 | | @ | LAA | W | 8-1 | | Freeland | L | Freeland | | Junis | R |
| 7/25/2021 | | | NYY | W | 7-4 | | Lambert,P | R | Buttrey | Biagini | Minor | L |
| 7/25/2021 | | @ | LAA | W | 5-3 | | Lambert,P | R | Lambert,P | Fry,J | Keuchel | L |
| 7/26/2021 | | | NYY | L | 3-13 | | Freeland | L | Freeland | | Flaherty,J | R |
| 7/26/2021 | | @ | LAA | W | 8-4 | | Smyly | L | Smyly | Osuna,R | Akin | L |
| 8/6/2021 | | | Det | L | 2-11 | | Supak | R | Supak | | Perez,Ma | L |
| 8/6/2021 | | @ | Cle | L | 1-5 | | Lambert,P | R | Lambert,P | | Honeywell | R |
| 8/7/2021 | | | Det | L | 3-7 | | Smyly | L | Smyly | | Webb,L | R |
| 8/7/2021 | | @ | Cle | W | 5-4 | | Freeland | L | Osuna,R | Buttrey | Woodruff | R |
| 8/8/2021 | | | Det | W | 3-1 | | Lambert,P | R | Lambert,P | Osuna,R | Happ,J.A. | L |
| 8/8/2021 | | @ | Cle | W | 8-7 | | Supak | R | Biagini | Osuna,R | Verlander | R |
| 8/9/2021 | | | Min | W | 5-0 | | Freeland | L | Freeland | | Ray,R | L |
| 8/9/2021 | | @ | ChW | W | 7-3 | | Reid-Foley | R | Biagini | Buttrey | Giolito | R |
| 8/10/2021 | | | Min | L | 5-8 | | Reid-Foley | R | Reid-Foley | | Paddack | R |
| 8/10/2021 | | @ | ChW | L | 6-11 | | Smyly | L | Smyly | | Porcello | R |
| 8/11/2021 | | | Min | W | 8-7 | | Supak | R | Biagini | Osuna,R | Gallen | R |
| 8/11/2021 | | @ | ChW | L | 1-9 | | Lambert,P | R | Lambert,P | | Bassitt | R |
| 8/13/2021 | | |  KCR | W | 14-8 | | Lambert,P | R | Buttrey | | Hudson,Dak | R |
| 8/13/2021 | | @ |  Was | W | 2-1 | | Supak | R | Supak | Cabrera,G | Barria | R |
| 8/14/2021 | | | KCR | W | 5-2 | | Freeland | L | Freeland | Osuna,R | Davies | R |
| 8/14/2021 | | @ | Was | W | 6-1 | | Reid-Foley | R | Reid-Foley | Biagini | Kuhl | R |
| 8/15/2021 | | | KCR | L | 1-3 | | Reid-Foley | R | Reid-Foley | | Fried | L |
| 8/15/2021 | | @ | Was | L | 1-10 | | Smyly | L | Smyly | | Pivetta | R |
| 8/16/2021 | | | KCR | W | 5-4 | | Supak | R | Supak | Biagini | Newsome | R |
| 8/16/2021 | | @ | Was | W | 2-1 | | Lambert,P | R | Lambert,P | Fry,J | Duplantier | R |
| 8/23/2021 | | | Was | L | 1-7 | | Lambert,P | R | Lambert,P | | Barria | R |
| 8/23/2021 | | @ | KCR | W | 9-8 | | Lambert,P | R | Cabrera,G | Osuna,R | Antone | R |
| 8/24/2021 | | | Was | W | 4-3 | | Reid-Foley | R | Osuna,R | | McKay,B | L |
| 8/24/2021 | | @ | KCR | L | 1-2 | | Reid-Foley | R | De Leon,J | | Hudson,Dak | R |
| 8/25/2021 | | | Was | W | 6-2 | | Supak | R | Supak | | Eflin | R |
| 8/25/2021 | | @ | KCR | L | 3-14 | | Supak | R | Supak | | Davies | R |
| 8/26/2021 | | | Was | W | 7-0 | | Freeland | L | Freeland | | Duplantier | R |
| 8/26/2021 | | @ | KCR | W | 7-4 | | Freeland | L | Freeland | | Thornton | R |
| 8/27/2021 | | | Mtl | L | 8-14 | | Yamaguchi | R | Yamaguchi | | Strahm | L |
| 8/27/2021 | | @ | Tex | L | 12-13 | 10 | Yamaguchi | R | Cabrera,G | | Matz | L |
| 8/28/2021 | | | Mtl | L | 1-6 | | Lambert,P | R | Lambert,P | | Bumgarner | L |
| 8/28/2021 | | @ | Tex | L | 2-3 | | Lambert,P | R | Lambert,P | | Hoffman | R |
| 8/29/2021 | | | Mtl | W | 11-1 | | Reid-Foley | R | Avilan | Romano,J | Anderson,Bre | L |
| 8/29/2021 | | @ | Tex | L | 4-9 | | Reid-Foley | R | Reid-Foley | | Alzolay | R |
| 8/30/2021 | | | Mtl | L | 2-4 | | Supak | R | Supak | | Thorpe | L |
| 8/30/2021 | | @ | Tex | W | 7-3 | 11 | Supak | R | Osuna,R | | Manaea | L |
| 9/7/2021 | | | ChW | L | 2-7 | | Freeland | L | Freeland | | Ohtani | R |
| 9/7/2021 | | @ | Min | L | 1-2 | 10 | Yamaguchi | R | Grimm | | Ray,R | L |
| 9/8/2021 | | | ChW | L | 1-8 | | Lambert,P | R | Lambert,P | | Giolito | R |
| 9/8/2021 | | @ | Min | W | 10-7 | | Smith,JoshD | L | Grimm | Romano,J | Paddack | R |
| 9/9/2021 | | | ChW | L | 7-12 | | Yamaguchi | R | Yamaguchi | | Bassitt | R |
| 9/9/2021 | | @ | Min | L | 5-6 | | Lambert,P | R | Lambert,P | | Lauer | L |
| 9/10/2021 | | @ | Bos | W | 9-1 | | Supak | R | Supak | | Pena,Fe | R |
| 9/10/2021 | | | LAA | W | 6-1 | | Supak | R | Supak | | Junis | R |
| 9/11/2021 | | @ | Bos | W | 4-0 | | Freeland | L | Freeland | | Clarke | R |
| 9/11/2021 | | | LAA | W | 4-2 | | Reid-Foley | R | Reid-Foley | Smith,JoshD | Houck | R |
| 9/12/2021 | | @ | Bos | W | 8-4 | | Yamaguchi | R | Yamaguchi | | Smeltzer | L |
| 9/12/2021 | | | LAA | W | 5-3 | | Freeland | L | Freeland | Grimm | Akin | L |
| 9/13/2021 | | @ | Bos | L | 4-8 | | Smith,JoshD | L | Smith,JoshD | | Rodriguez,E | L |
| 9/13/2021 | | | LAA | W | 7-6 | | Lambert,P | R | Smith,JoshD | Osuna,R | Hearn | L |
| 9/24/2021 | | | Cle | L | 5-6 | | Merryweather | R | Merryweather | | Hendricks | R |
| 9/24/2021 | | @ | Det | L | 2-3 | 10 | Merryweather | R | Grimm | | Perez,Ma | L |
| 9/25/2021 | | | Cle | W | 10-9 | | Supak | R | Smith,JoshD | Avilan | Keller, Mitch | R |
| 9/25/2021 | | @ | Det | L | 2-13 | | Sharp | R | Sharp | | Duffy,D | L |
| 9/26/2021 | | | Cle | W | 7-6 | | Plutko | R | Grimm | | Davidson,T | L |
| 9/26/2021 | | @ | Det | L | 5-9 | | Lambert,P | R | Lambert,P | | Happ,J.A. | L |
| 9/27/2021 | | | Det | L | 0-2 | | Freeland | L | Freeland | | Beeks | L |
| 9/27/2021 | | @ | ChW | W | 11-8 | | Supak | R | Supak | | Giolito | R |
| 9/28/2021 | | | Det | W | 7-5 | | Lambert,P | R | Lambert,P | Smith,JoshD | Rogers,Tr | L |
| 9/28/2021 | | @ | ChW | L | 2-3 | | Plutko | R | Plutko | | Porcello | R |
| Other |
| Game information | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | | W | L | Pct | L10 | Strk | Gm# |
| 4/8/2021 | | | Bos | L | | 2 | 3 | | 0 | 1 | .000 | 0-1 | L1 | 1 |
| 4/8/2021 | | @ | Oak | L | | 1 | 4 | | 0 | 2 | .000 | 0-2 | L2 | 2 |
| 4/9/2021 | | | Bos | L | | 0 | 3 | | 0 | 3 | .000 | 0-3 | L3 | 3 |
| 4/9/2021 | | @ | Oak | L | | 6 | 7 | | 0 | 4 | .000 | 0-4 | L4 | 4 |
| 4/10/2021 | | | Bos | W | Gallo | 4 | 0 | | 1 | 4 | .200 | 1-4 | W1 | 5 |
| 4/10/2021 | | @ | Oak | L | | 3 | 5 | | 1 | 5 | .167 | 1-5 | L1 | 6 |
| 4/11/2021 | | | Bos | W | Perez,S | 6 | 2 | | 2 | 5 | .286 | 2-5 | W1 | 7 |
| 4/11/2021 | | @ | Oak | W | Perez,S | 8 | 1 | | 3 | 5 | .375 | 3-5 | W2 | 8 |
| 4/12/2021 | | | Min | L | | 7 | 13 | | 3 | 6 | .333 | 3-6 | L1 | 9 |
| 4/12/2021 | | @ | ChW | W | Villar,J | 8 | 6 | | 4 | 6 | .400 | 4-6 | W1 | 10 |
| 4/13/2021 | | | Min | W | Suarez,E | 8 | 6 | | 5 | 6 | .455 | 5-5 | W2 | 11 |
| 4/13/2021 | | @ | ChW | W | Judge | 7 | 3 | | 6 | 6 | .500 | 6-4 | W3 | 12 |
| 4/14/2021 | | | Min | L | | 2 | 12 | | 6 | 7 | .462 | 6-4 | L1 | 13 |
| 4/14/2021 | | @ | ChW | L | | 2 | 6 | | 6 | 8 | .429 | 6-4 | L2 | 14 |
| 4/16/2021 | | | Det | L | | 3 | 9 | | 6 | 9 | .400 | 5-5 | L3 | 15 |
| 4/16/2021 | | @ | Cle | L | | 0 | 4 | | 6 | 10 | .375 | 5-5 | L4 | 16 |
| 4/17/2021 | | | Det | W | Aquino | 3 | 2 | | 7 | 10 | .412 | 5-5 | W1 | 17 |
| 4/17/2021 | | @ | Cle | L | | 2 | 6 | | 7 | 11 | .389 | 4-6 | L1 | 18 |
| 4/18/2021 | | | Det | W | Aquino | 6 | 1 | | 8 | 11 | .421 | 5-5 | W1 | 19 |
| 4/18/2021 | | @ | Cle | L | | 3 | 8 | | 8 | 12 | .400 | 4-6 | L1 | 20 |
| 4/23/2021 | | | Pit | W | Guerrero Jr. | 9 | 7 | | 9 | 12 | .429 | 4-6 | W1 | 21 |
| 4/24/2021 | | | Pit | W | Villar,J | 7 | 3 | | 10 | 12 | .455 | 4-6 | W2 | 22 |
| 4/25/2021 | | | Pit | W | Tsutsugo | 7 | 6 | | 11 | 12 | .478 | 5-5 | W3 | 23 |
| 4/27/2021 | | | Atl | W | Tsutsugo | 2 | 1 | | 12 | 12 | .500 | 6-4 | W4 | 24 |
| 4/28/2021 | | | Atl | L | | 2 | 4 | | 12 | 13 | .480 | 6-4 | L1 | 25 |
| 4/29/2021 | | | Atl | W | Judge | 5 | 2 | | 13 | 13 | .500 | 7-3 | W1 | 26 |
| 5/3/2021 | | @ | Mtl | W | Stewart,CG | 4 | 3 | | 14 | 13 | .519 | 7-3 | W2 | 27 |
| 5/3/2021 | | | Sea | W | Judge | 8 | 3 | | 15 | 13 | .536 | 8-2 | W3 | 28 |
| 5/4/2021 | | @ | Mtl | W | Judge | 6 | 3 | | 16 | 13 | .552 | 8-2 | W4 | 29 |
| 5/4/2021 | | | Sea | L | | 5 | 9 | | 16 | 14 | .533 | 8-2 | L1 | 30 |
| 5/5/2021 | | @ | Mtl | W | Judge | 10 | 4 | | 17 | 14 | .548 | 8-2 | W1 | 31 |
| 5/5/2021 | | | Sea | W | Villar,J | 8 | 4 | | 18 | 14 | .563 | 8-2 | W2 | 32 |
| 5/6/2021 | | @ | Mtl | W | Stewart,CG | 4 | 3 | | 19 | 14 | .576 | 8-2 | W3 | 33 |
| 5/6/2021 | | | Sea | W | Aquino | 5 | 4 | | 20 | 14 | .588 | 8-2 | W4 | 34 |
| 5/7/2021 | | @ | Col | L | | 4 | 7 | | 20 | 15 | .571 | 8-2 | L1 | 35 |
| 5/8/2021 | | @ | Col | L | | 4 | 5 | | 20 | 16 | .556 | 7-3 | L2 | 36 |
| 5/9/2021 | | @ | Col | L | | 3 | 11 | | 20 | 17 | .541 | 6-4 | L3 | 37 |
| 5/11/2021 | | @ | SFG | L | | 1 | 2 | | 20 | 18 | .526 | 5-5 | L4 | 38 |
| 5/12/2021 | | @ | SFG | L | | 5 | 6 | | 20 | 19 | .513 | 4-6 | L5 | 39 |
| 5/13/2021 | | @ | SFG | W | Biggio | 7 | 5 | | 21 | 19 | .525 | 5-5 | W1 | 40 |
| 5/24/2021 | | @ | Bal | L | | 3 | 4 | | 21 | 20 | .512 | 4-6 | L1 | 41 |
| 5/24/2021 | | | Tex | L | | 5 | 7 | | 21 | 21 | .500 | 3-7 | L2 | 42 |
| 5/25/2021 | | @ | Bal | L | | 2 | 3 | | 21 | 22 | .488 | 2-8 | L3 | 43 |
| 5/25/2021 | | | Tex | W | Perez,S | 12 | 4 | | 22 | 22 | .500 | 2-8 | W1 | 44 |
| 5/26/2021 | | @ | Bal | W | Judge | 6 | 0 | | 23 | 22 | .511 | 3-7 | W2 | 45 |
| 5/26/2021 | | | Tex | L | | 3 | 5 | | 23 | 23 | .500 | 3-7 | L1 | 46 |
| 5/27/2021 | | @ | Bal | W | Judge | 10 | 9 | | 24 | 23 | .511 | 4-6 | W1 | 47 |
| 5/27/2021 | | | Tex | W | Judge | 9 | 5 | | 25 | 23 | .521 | 5-5 | W2 | 48 |
| 5/28/2021 | | | ChW | W | Adames,W | 13 | 8 | | 26 | 23 | .531 | 6-4 | W3 | 49 |
| 5/28/2021 | | @ | Min | W | Villar,J | 11 | 2 | | 27 | 23 | .540 | 6-4 | W4 | 50 |
| 5/29/2021 | | | ChW | W | Tsutsugo | 20 | 5 | | 28 | 23 | .549 | 7-3 | W5 | 51 |
| 5/29/2021 | | @ | Min | W | Tsutsugo | 7 | 4 | | 29 | 23 | .558 | 8-2 | W6 | 52 |
| 5/30/2021 | | | ChW | L | | 2 | 4 | | 29 | 24 | .547 | 8-2 | L1 | 53 |
| 5/30/2021 | | @ | Min | L | | 1 | 5 | | 29 | 25 | .537 | 7-3 | L2 | 54 |
| 6/1/2021 | | @ | NYY | L | | 2 | 3 | | 29 | 26 | .527 | 6-4 | L3 | 55 |
| 6/1/2021 | | | Oak | L | | 2 | 4 | | 29 | 27 | .518 | 6-4 | L4 | 56 |
| 6/2/2021 | | @ | NYY | L | | 2 | 3 | | 29 | 28 | .509 | 5-5 | L5 | 57 |
| 6/2/2021 | | | Oak | W | Suarez,E | 3 | 1 | | 30 | 28 | .517 | 5-5 | W1 | 58 |
| 6/3/2021 | | @ | NYY | L | | 1 | 3 | | 30 | 29 | .508 | 4-6 | L1 | 59 |
| 6/3/2021 | | | Oak | W | Villar,J | 3 | 2 | | 31 | 29 | .517 | 4-6 | W1 | 60 |
| 6/4/2021 | | @ | NYY | W | Biggio | 2 | 0 | | 32 | 29 | .525 | 4-6 | W2 | 61 |
| 6/4/2021 | | | Oak | L | | 1 | 2 | | 32 | 30 | .516 | 3-7 | L1 | 62 |
| 6/8/2021 | | | Phi | W | Suarez,E | 4 | 2 | | 33 | 30 | .524 | 4-6 | W1 | 63 |
| 6/9/2021 | | | Phi | L | | 1 | 6 | | 33 | 31 | .516 | 4-6 | L1 | 64 |
| 6/10/2021 | | | Phi | L | | 3 | 6 | | 33 | 32 | .508 | 4-6 | L2 | 65 |
| 6/11/2021 | | | Mia | L | | 1 | 3 | | 33 | 33 | .500 | 4-6 | L3 | 66 |
| 6/12/2021 | | | Mia | W | Perez,S | 13 | 3 | | 34 | 33 | .507 | 5-5 | W1 | 67 |
| 6/13/2021 | | | Mia | L | | 0 | 1 | | 34 | 34 | .500 | 4-6 | L1 | 68 |
| 6/15/2021 | | | NYM | L | | 2 | 4 | | 34 | 35 | .493 | 4-6 | L2 | 69 |
| 6/16/2021 | | | NYM | L | | 4 | 7 | | 34 | 36 | .486 | 3-7 | L3 | 70 |
| 6/17/2021 | | | NYM | W | Adames,W | 3 | 2 | | 35 | 36 | .493 | 3-7 | W1 | 71 |
| 6/18/2021 | | @ | Ari | L | | 2 | 6 | | 35 | 37 | .486 | 3-7 | L1 | 72 |
| 6/19/2021 | | @ | Ari | W | Judge | 2 | 1 | | 36 | 37 | .493 | 3-7 | W1 | 73 |
| 6/20/2021 | | @ | Ari | L | | 4 | 5 | | 36 | 38 | .486 | 3-7 | L1 | 74 |
| 6/22/2021 | | @ | SDP | W | Biggio | 6 | 0 | | 37 | 38 | .493 | 4-6 | W1 | 75 |
| 6/23/2021 | | @ | SDP | W | Biggio | 8 | 7 | | 38 | 38 | .500 | 5-5 | W2 | 76 |
| 6/24/2021 | | @ | SDP | L | | 0 | 3 | | 38 | 39 | .494 | 4-6 | L1 | 77 |
| 6/25/2021 | | @ | LAD | W | Guerrero Jr. | 5 | 4 | | 39 | 39 | .500 | 5-5 | W1 | 78 |
| 6/26/2021 | | @ | LAD | L | | 2 | 10 | | 39 | 40 | .494 | 5-5 | L1 | 79 |
| 6/27/2021 | | @ | LAD | W | Perez,S | 9 | 3 | | 40 | 40 | .500 | 6-4 | W1 | 80 |
| 7/15/2021 | | | Bal | L | | 2 | 9 | | 40 | 41 | .494 | 5-5 | L1 | 81 |
| 7/15/2021 | | @ | Sea | L | | 2 | 9 | | 40 | 42 | .488 | 5-5 | L2 | 82 |
| 7/16/2021 | | | Bal | W | Gallo | 9 | 7 | | 41 | 42 | .494 | 5-5 | W1 | 83 |
| 7/16/2021 | | @ | Sea | L | | 5 | 8 | | 41 | 43 | .488 | 5-5 | L1 | 84 |
| 7/17/2021 | | | Bal | W | Villar,J | 9 | 3 | | 42 | 43 | .494 | 5-5 | W1 | 85 |
| 7/17/2021 | | @ | Sea | L | | 4 | 7 | | 42 | 44 | .488 | 4-6 | L1 | 86 |
| 7/18/2021 | | | Bal | L | | 2 | 10 | | 42 | 45 | .483 | 4-6 | L2 | 87 |
| 7/18/2021 | | @ | Sea | L | | 1 | 2 | | 42 | 46 | .477 | 3-7 | L3 | 88 |
| 7/19/2021 | | | Cle | L | | 8 | 13 | | 42 | 47 | .472 | 3-7 | L4 | 89 |
| 7/19/2021 | | @ | Det | L | | 5 | 10 | | 42 | 48 | .467 | 2-8 | L5 | 90 |
| 7/20/2021 | | | Cle | W | Suarez,E | 6 | 3 | | 43 | 48 | .473 | 3-7 | W1 | 91 |
| 7/20/2021 | | @ | Det | L | | 6 | 8 | | 43 | 49 | .467 | 3-7 | L1 | 92 |
| 7/21/2021 | | | Cle | L | | 2 | 4 | | 43 | 50 | .462 | 2-8 | L2 | 93 |
| 7/21/2021 | | @ | Det | W | Adames,W | 8 | 4 | | 44 | 50 | .468 | 3-7 | W1 | 94 |
| 7/23/2021 | | | NYY | W | Biggio | 14 | 12 | | 45 | 50 | .474 | 3-7 | W2 | 95 |
| 7/23/2021 | | @ | LAA | L | | 1 | 3 | | 45 | 51 | .469 | 3-7 | L1 | 96 |
| 7/24/2021 | | | NYY | W | Judge | 4 | 2 | | 46 | 51 | .474 | 4-6 | W1 | 97 |
| 7/24/2021 | | @ | LAA | W | Tsutsugo | 8 | 1 | | 47 | 51 | .480 | 5-5 | W2 | 98 |
| 7/25/2021 | | | NYY | W | Suarez,E | 7 | 4 | | 48 | 51 | .485 | 6-4 | W3 | 99 |
| 7/25/2021 | | @ | LAA | W | Suarez,E | 5 | 3 | | 49 | 51 | .490 | 7-3 | W4 | 100 |
| 7/26/2021 | | | NYY | L | | 3 | 13 | | 49 | 52 | .485 | 6-4 | L1 | 101 |
| 7/26/2021 | | @ | LAA | W | Perez,S | 8 | 4 | | 50 | 52 | .490 | 7-3 | W1 | 102 |
| 8/6/2021 | | | Det | L | | 2 | 11 | | 50 | 53 | .485 | 7-3 | L1 | 103 |
| 8/6/2021 | | @ | Cle | L | | 1 | 5 | | 50 | 54 | .481 | 6-4 | L2 | 104 |
| 8/7/2021 | | | Det | L | | 3 | 7 | | 50 | 55 | .476 | 5-5 | L3 | 105 |
| 8/7/2021 | | @ | Cle | W | Adames,W | 5 | 4 | | 51 | 55 | .481 | 6-4 | W1 | 106 |
| 8/8/2021 | | | Det | W | Suarez,E | 3 | 1 | | 52 | 55 | .486 | 6-4 | W2 | 107 |
| 8/8/2021 | | @ | Cle | W | Stewart,CG | 8 | 7 | | 53 | 55 | .491 | 6-4 | W3 | 108 |
| 8/9/2021 | | | Min | W | Biggio | 5 | 0 | | 54 | 55 | .495 | 6-4 | W4 | 109 |
| 8/9/2021 | | @ | ChW | W | Perez,S | 7 | 3 | | 55 | 55 | .500 | 6-4 | W5 | 110 |
| 8/10/2021 | | | Min | L | | 5 | 8 | | 55 | 56 | .495 | 6-4 | L1 | 111 |
| 8/10/2021 | | @ | ChW | L | | 6 | 11 | | 55 | 57 | .491 | 5-5 | L2 | 112 |
| 8/11/2021 | | | Min | W | Adames,W | 8 | 7 | | 56 | 57 | .496 | 6-4 | W1 | 113 |
| 8/11/2021 | | @ | ChW | L | | 1 | 9 | | 56 | 58 | .491 | 6-4 | L1 | 114 |
| 8/13/2021 | | | KCR | W | Perez,S | 14 | 8 | | 57 | 58 | .496 | 7-3 | W1 | 115 |
| 8/13/2021 | | @ | Was | W | Gallo | 2 | 1 | | 58 | 58 | .500 | 7-3 | W2 | 116 |
| 8/14/2021 | | | KCR | W | Judge | 5 | 2 | | 59 | 58 | .504 | 7-3 | W3 | 117 |
| 8/14/2021 | | @ | Was | W | Guerrero Jr. | 6 | 1 | | 60 | 58 | .508 | 7-3 | W4 | 118 |
| 8/15/2021 | | | KCR | L | | 1 | 3 | | 60 | 59 | .504 | 6-4 | L1 | 119 |
| 8/15/2021 | | @ | Was | L | | 1 | 10 | | 60 | 60 | .500 | 5-5 | L2 | 120 |
| 8/16/2021 | | | KCR | W | Tsutsugo | 5 | 4 | | 61 | 60 | .504 | 6-4 | W1 | 121 |
| 8/16/2021 | | @ | Was | W | Suarez,E | 2 | 1 | | 62 | 60 | .508 | 7-3 | W2 | 122 |
| 8/23/2021 | | | Was | L | | 1 | 7 | | 62 | 61 | .504 | 6-4 | L1 | 123 |
| 8/23/2021 | | @ | KCR | W | Gallo | 9 | 8 | | 63 | 61 | .508 | 7-3 | W1 | 124 |
| 8/24/2021 | | | Was | W | Biggio | 4 | 3 | | 64 | 61 | .512 | 7-3 | W2 | 125 |
| 8/24/2021 | | @ | KCR | L | | 1 | 2 | | 64 | 62 | .508 | 6-4 | L1 | 126 |
| 8/25/2021 | | | Was | W | Guerrero Jr. | 6 | 2 | | 65 | 62 | .512 | 6-4 | W1 | 127 |
| 8/25/2021 | | @ | KCR | L | | 3 | 14 | | 65 | 63 | .508 | 5-5 | L1 | 128 |
| 8/26/2021 | | | Was | W | Aquino | 7 | 0 | | 66 | 63 | .512 | 6-4 | W1 | 129 |
| 8/26/2021 | | @ | KCR | W | Suarez,E | 7 | 4 | | 67 | 63 | .515 | 7-3 | W2 | 130 |
| 8/27/2021 | | | Mtl | L | | 8 | 14 | | 67 | 64 | .511 | 6-4 | L1 | 131 |
| 8/27/2021 | | @ | Tex | L | | 12 | 13 | | 67 | 65 | .508 | 5-5 | L2 | 132 |
| 8/28/2021 | | | Mtl | L | | 1 | 6 | | 67 | 66 | .504 | 5-5 | L3 | 133 |
| 8/28/2021 | | @ | Tex | L | | 2 | 3 | | 67 | 67 | .500 | 4-6 | L4 | 134 |
| 8/29/2021 | | | Mtl | W | Tsutsugo | 11 | 1 | | 68 | 67 | .504 | 4-6 | W1 | 135 |
| 8/29/2021 | | @ | Tex | L | | 4 | 9 | | 68 | 68 | .500 | 4-6 | L1 | 136 |
| 8/30/2021 | | | Mtl | L | | 2 | 4 | | 68 | 69 | .496 | 3-7 | L2 | 137 |
| 8/30/2021 | | @ | Tex | W | Suarez,E | 7 | 3 | | 69 | 69 | .500 | 4-6 | W1 | 138 |
| 9/7/2021 | | | ChW | L | | 2 | 7 | | 69 | 70 | .496 | 3-7 | L1 | 139 |
| 9/7/2021 | | @ | Min | L | | 1 | 2 | | 69 | 71 | .493 | 2-8 | L2 | 140 |
| 9/8/2021 | | | ChW | L | | 1 | 8 | | 69 | 72 | .489 | 2-8 | L3 | 141 |
| 9/8/2021 | | @ | Min | W | Suarez,E | 10 | 7 | | 70 | 72 | .493 | 3-7 | W1 | 142 |
| 9/9/2021 | | | ChW | L | | 7 | 12 | | 70 | 73 | .490 | 3-7 | L1 | 143 |
| 9/9/2021 | | @ | Min | L | | 5 | 6 | | 70 | 74 | .486 | 3-7 | L2 | 144 |
| 9/10/2021 | | @ | Bos | W | Biggio | 9 | 1 | | 71 | 74 | .490 | 3-7 | W1 | 145 |
| 9/10/2021 | | | LAA | W | Tsutsugo | 6 | 1 | | 72 | 74 | .493 | 4-6 | W2 | 146 |
| 9/11/2021 | | @ | Bos | W | Aquino | 4 | 0 | | 73 | 74 | .497 | 5-5 | W3 | 147 |
| 9/11/2021 | | | LAA | W | | 4 | 2 | | 74 | 74 | .500 | 5-5 | W4 | 148 |
| 9/12/2021 | | @ | Bos | W | Judge | 8 | 4 | | 75 | 74 | .503 | 6-4 | W5 | 149 |
| 9/12/2021 | | | LAA | W | Guerrero Jr. | 5 | 3 | | 76 | 74 | .507 | 7-3 | W6 | 150 |
| 9/13/2021 | | @ | Bos | L | | 4 | 8 | | 76 | 75 | .503 | 7-3 | L1 | 151 |
| 9/13/2021 | | | LAA | W | Guerrero Jr. | 7 | 6 | | 77 | 75 | .507 | 7-3 | W1 | 152 |
| 9/24/2021 | | | Cle | L | | 5 | 6 | | 77 | 76 | .503 | 7-3 | L1 | 153 |
| 9/24/2021 | | @ | Det | L | | 2 | 3 | | 77 | 77 | .500 | 7-3 | L2 | 154 |
| 9/25/2021 | | | Cle | W | Wade,L | 10 | 9 | | 78 | 77 | .503 | 7-3 | W1 | 155 |
| 9/25/2021 | | @ | Det | L | | 2 | 13 | | 78 | 78 | .500 | 6-4 | L1 | 156 |
| 9/26/2021 | | | Cle | W | Stewart,CG | 7 | 6 | | 79 | 78 | .503 | 6-4 | W1 | 157 |
| 9/26/2021 | | @ | Det | L | | 5 | 9 | | 79 | 79 | .500 | 5-5 | L1 | 158 |
| 9/27/2021 | | | Det | L | | 0 | 2 | | 79 | 80 | .497 | 4-6 | L2 | 159 |
| 9/27/2021 | | @ | ChW | W | Adames,W | 11 | 8 | | 80 | 80 | .500 | 4-6 | W1 | 160 |
| 9/28/2021 | | | Det | W | Perez,S | 7 | 5 | | 81 | 80 | .503 | 5-5 | W2 | 161 |
| 9/28/2021 | | @ | ChW | L | | 2 | 3 | | 81 | 81 | .500 | 4-6 | L1 | 162 |