Team game results -- 2010 Chicago White Sox
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/8/2010 | | @ |  Bos | W | 3-2 | | Wolf | L | Wolf | Hoffman | Greinke | R |
| 4/8/2010 | | |  KCR | W | 6-5 | | Zito | L | Vizcaino | | Padilla,V | R |
| 4/9/2010 | | @ | Bos | W | 5-1 | | Zito | L | Zito | | Washburn | L |
| 4/9/2010 | | | KCR | L | 4-7 | | Wolf | L | Wolf | | Volstad | R |
| 4/10/2010 | | @ | Bos | W | 3-1 | | Porcello | R | Porcello | Hoffman | Kazmir | L |
| 4/10/2010 | | | KCR | W | 8-7 | | Porcello | R | Porcello | Calero | Meche | R |
| 4/11/2010 | | @ | Bos | L | 1-7 | | Hammel | R | Hammel | | Lohse | R |
| 4/11/2010 | | | KCR | W | 3-1 | | Hammel | R | Hammel | Green,S | Beckett | R |
| 4/12/2010 | | |  Tor | W | 3-1 | | Purcey | L | Purcey | Hoffman | Slowey | R |
| 4/12/2010 | | @ |  Cle | W | 5-3 | | Purcey | L | Vizcaino | Hoffman | Tomko | R |
| 4/13/2010 | | | Tor | L | 2-5 | | Zito | L | Zito | | Duke | L |
| 4/13/2010 | | @ | Cle | W | 2-1 | 12 | Wolf | L | Hoffman | Calero | Verlander | R |
| 4/14/2010 | | | Tor | W | 11-5 | | Wolf | L | Wolf | | Scherzer | R |
| 4/14/2010 | | @ | Cle | L | 2-4 | | Zito | L | Zito | | Romero,R | L |
| 4/16/2010 | | |  Min | L | 3-9 | | Porcello | R | Porcello | | Johnson,Jo | R |
| 4/16/2010 | | @ |  Det | W | 4-1 | | Porcello | R | Porcello | Nippert | Rzepczynski | L |
| 4/17/2010 | | | Min | L | 5-6 | | Hammel | R | Calero | | Wakefield | R |
| 4/17/2010 | | @ | Det | L | 3-6 | | Hammel | R | Hammel | | Morton | R |
| 4/18/2010 | | | Min | W | 10-9 | | Zito | L | Zito | Hoffman | Liriano | L |
| 4/18/2010 | | @ | Det | W | 3-0 | | Wolf | L | Wolf | Hoffman | Rowland-Smith | L |
| 4/23/2010 | | |  Col | L | 2-4 | | Wolf | L | Wolf | | Garland | R |
| 4/24/2010 | | | Col | W | 7-0 | | Porcello | R | Porcello | | Parra,M | L |
| 4/25/2010 | | | Col | L | 5-6 | | Hammel | R | Hoffman | | Hochevar | R |
| 4/27/2010 | | |  LAD | W | 3-1 | | Zito | L | Zito | Hoffman | Zambrano | R |
| 4/28/2010 | | | LAD | L | 3-9 | | Niese | L | Niese | | Lilly | L |
| 4/29/2010 | | | LAD | W | 3-0 | | Wolf | L | Wolf | Hoffman | Rodriguez,W | L |
| 4/30/2010 | | @ |  ChC | L | 6-7 | | Niese | L | Niese | | Jimenez | R |
| 5/1/2010 | | @ | ChC | L | 5-6 | | Porcello | R | Hoffman | | Johnson,Ra | L |
| 5/2/2010 | | @ | ChC | W | 4-3 | | Hammel | R | Hammel | Hoffman | Ohlendorf | R |
| 5/3/2010 | | @ |  Mil | W | 10-4 | | Wolf | L | Wolf | | Wainwright | R |
| 5/4/2010 | | @ | Mil | W | 7-4 | | Zito | L | Zito | Hoffman | Olsen | L |
| 5/5/2010 | | @ | Mil | W | 6-3 | | Niese | L | Niese | Vizcaino | Paulino,F | R |
| 5/7/2010 | | @ |  NYY | W | 8-7 | | Porcello | R | Hoffman | Vizcaino | Carpenter,C | R |
| 5/7/2010 | | |  Tex | W | 3-1 | | Porcello | R | Porcello | Hoffman | Snell | R |
| 5/8/2010 | | @ | NYY | W | 8-4 | | Hammel | R | Hammel | | Santana,E | R |
| 5/8/2010 | | | Tex | W | 10-5 | | Hammel | R | Hawksworth | | Looper | R |
| 5/9/2010 | | @ | NYY | L | 4-5 | | Wolf | L | Wolf | | Danks | L |
| 5/9/2010 | | | Tex | L | 3-4 | | Zito | L | Zito | | Bergesen | R |
| 5/10/2010 | | @ | NYY | W | 11-7 | | Niese | L | Nippert | | Maholm | L |
| 5/10/2010 | | | Tex | W | 5-4 | | Wolf | L | Wolf | Hoffman | Richard,Cl | L |
| 5/27/2010 | | @ |  Bal | L | 1-8 | | Zito | L | Zito | | Latos | R |
| 5/27/2010 | | |  LAA | L | 3-5 | | Wolf | L | Wolf | | Saunders,J | L |
| 5/28/2010 | | @ | Bal | L | 2-3 | | Purcey | L | Purcey | | Suppan | R |
| 5/28/2010 | | | LAA | W | 7-3 | | Purcey | L | Purcey | | Dempster | R |
| 5/29/2010 | | @ | Bal | W | 12-4 | | Porcello | R | Porcello | | Garza | R |
| 5/29/2010 | | | LAA | W | 4-2 | | Porcello | R | Porcello | Calero | Happ | L |
| 5/30/2010 | | @ | Bal | L | 0-4 | | Hammel | R | Hammel | | Pavano | R |
| 5/30/2010 | | | LAA | L | 2-6 | | Hammel | R | Hammel | | Miller,A | L |
| 5/31/2010 | | @ | Tor | W | 11-3 | | Wolf | L | Wolf | | Slowey | R |
| 5/31/2010 | | | Cle | W | 12-4 | | Zito | L | Zito | | Tomko | R |
| 6/1/2010 | | @ | Tor | W | 4-2 | | Zito | L | Zito | Accardo | Harang | R |
| 6/1/2010 | | | Cle | L | 5-6 | 10 | Wolf | L | Hoffman | | Buchholz | R |
| 6/2/2010 | | @ | Tor | L | 4-7 | | Purcey | L | Purcey | | Bailey,H | R |
| 6/2/2010 | | | Cle | L | 1-5 | | Purcey | L | Purcey | | Verlander | R |
| 6/4/2010 | | | Bos | W | 2-1 | | Porcello | R | Porcello | Calero | Greinke | R |
| 6/4/2010 | | @ |  Oak | W | 5-4 | 10 | Porcello | R | Calero | Hawksworth | Sabathia | L |
| 6/5/2010 | | | Bos | W | 9-4 | | Hammel | R | Hammel | | Washburn | L |
| 6/5/2010 | | @ | Oak | L | 4-7 | | Hammel | R | Hammel | | Peavy | R |
| 6/6/2010 | | | Bos | W | 6-4 | | Zito | L | Zito | Nippert | Redding | R |
| 6/6/2010 | | @ | Oak | W | 5-4 | | Wolf | L | Wolf | Accardo | Hernandez,Li | R |
| 6/7/2010 | | | Bos | L | 2-3 | 10 | Wolf | L | Hoffman | | Kazmir | L |
| 6/7/2010 | | @ | Oak | W | 8-4 | | Zito | L | Zito | | Berken | R |
| 6/8/2010 | | |  SDP | L | 1-5 | | Zito | L | Zito | | Kuroda | R |
| 6/9/2010 | | | SDP | W | 7-5 | | Hernandez,Da | R | Mickolio | Calero | Lee,Cl | L |
| 6/10/2010 | | | SDP | W | 5-4 | | Porcello | R | Porcello | Calero | Arroyo | R |
| 6/11/2010 | | |  SFG | L | 7-9 | 12 | Hammel | R | Green,S | | Guthrie | R |
| 6/12/2010 | | | SFG | L | 4-6 | | Wolf | L | Wolf | | Shields,J | R |
| 6/13/2010 | | | SFG | L | 3-9 | | Zito | L | Zito | | Burnett,A | R |
| 6/15/2010 | | |  Ari | L | 2-7 | | Hernandez,Da | R | Hernandez,Da | | Lester | L |
| 6/16/2010 | | | Ari | W | 10-9 | | Porcello | R | Calero | Hawksworth | Huff,D | L |
| 6/17/2010 | | | Ari | L | 2-11 | | Hammel | R | Hammel | | Mazzaro | R |
| 6/18/2010 | | @ |  Cin | L | 2-3 | 10 | Porcello | R | Nippert | | Thompson,B | R |
| 6/19/2010 | | @ | Cin | L | 4-8 | | Hernandez,Da | R | Hernandez,Da | | Billingsley | R |
| 6/20/2010 | | @ | Cin | L | 9-10 | | Hammel | R | Mickolio | | Garcia | R |
| 6/21/2010 | | @ |  Hou | W | 4-1 | | Wolf | L | Wolf | Hawksworth | Buehrle | L |
| 6/22/2010 | | @ | Hou | W | 9-8 | | Zito | L | Nippert | Hawksworth | Pineiro | R |
| 6/23/2010 | | @ | Hou | W | 9-4 | | Porcello | R | Hoffman | | Waters | L |
| 6/25/2010 | | @ |  StL | W | 6-4 | | Hernandez,Da | R | Nippert | Green,S | Feldman | R |
| 6/26/2010 | | @ | StL | W | 5-3 | | Hammel | R | Hammel | Accardo | Pelfrey | R |
| 6/27/2010 | | @ | StL | L | 4-8 | | Wolf | L | Green,S | | Niemann | R |
| 7/12/2010 | | | Det | W | 9-3 | | Zito | L | Zito | | Wellemeyer | R |
| 7/12/2010 | | @ | Min | L | 1-5 | | Wolf | L | Wolf | | Johnson,Jo | R |
| 7/13/2010 | | | Det | W | 3-2 | | Wolf | L | Hawksworth | | Morton | R |
| 7/13/2010 | | @ | Min | L | 1-5 | | Porcello | R | Porcello | | Jackson,E | R |
| 7/14/2010 | | | Det | W | 5-0 | | Purcey | L | Purcey | | Millwood | R |
| 7/14/2010 | | @ | Min | L | 3-7 | | Hammel | R | Hammel | | Richmond | R |
| 7/15/2010 | | |  Sea | W | 5-1 | | Wolf | L | Wolf | | Gorzelanny | L |
| 7/15/2010 | | @ |  Was | W | 4-3 | | Purcey | L | Calero | | Hanson,T | R |
| 7/16/2010 | | | Sea | L | 3-7 | | Zito | L | Zito | | Gaudin | R |
| 7/16/2010 | | @ | Was | W | 6-1 | | Zito | L | Zito | | Colon,B | R |
| 7/17/2010 | | | Sea | W | 5-4 | 10 | Hernandez,Da | R | Calero | | Santana,J | L |
| 7/17/2010 | | @ | Was | W | 5-4 | | Wolf | L | Green,S | Calero | Lannan | L |
| 7/18/2010 | | | Sea | W | 7-3 | | Porcello | R | Porcello | Mickolio | Cueto | R |
| 7/18/2010 | | @ | Was | W | 3-1 | | Porcello | R | Porcello | Calero | Marquis | R |
| 7/20/2010 | | | Bal | W | 8-5 | | Purcey | L | Hawksworth | Green,S | Latos | R |
| 7/20/2010 | | @ | LAA | W | 8-7 | | Hammel | R | Hawksworth | Bruney | Happ | L |
| 7/21/2010 | | | Bal | W | 12-5 | | Hammel | R | Hammel | | Suppan | R |
| 7/21/2010 | | @ | LAA | L | 9-13 | | Purcey | L | Green,S | | Nieve | R |
| 7/22/2010 | | | Bal | W | 5-4 | 11 | Porcello | R | Hawksworth | | Duensing | L |
| 7/22/2010 | | @ | LAA | W | 12-7 | | Zito | L | Zito | | Eveland | L |
| 7/23/2010 | | | Bal | W | 4-3 | | Zito | L | Zito | Hoffman | Ray,R | R |
| 7/23/2010 | | @ | LAA | W | 6-3 | | Wolf | L | Wolf | Rosa | Saunders,J | L |
| 7/30/2010 | | @ | Tor | L | 1-10 | | Porcello | R | Porcello | | Duke | L |
| 7/30/2010 | | | Cle | L | 1-7 | | Zito | L | Zito | | Hampton | L |
| 7/31/2010 | | @ | Tor | L | 4-8 | | Purcey | L | Purcey | | Scherzer | R |
| 7/31/2010 | | | Cle | L | 5-6 | | Porcello | R | Nippert | | Buchholz | R |
| 8/1/2010 | | @ | Tor | W | 12-6 | | Zito | L | Zito | | Harang | R |
| 8/1/2010 | | | Cle | L | 1-16 | | Hammel | R | Hammel | | Lackey | R |
| 8/2/2010 | | | Tor | W | 8-7 | 11 | Wolf | L | Hoffman | | Scherzer | R |
| 8/2/2010 | | @ | Cle | W | 10-3 | | Wolf | L | Wolf | | Verlander | R |
| 8/3/2010 | | | Tor | W | 3-2 | | Purcey | L | Nippert | Hoffman | Cecil | L |
| 8/3/2010 | | @ | Cle | W | 9-3 | | Hammel | R | Hammel | | Buchholz | R |
| 8/4/2010 | | | Tor | L | 1-3 | | Zito | L | Zito | | Norris | R |
| 8/4/2010 | | @ | Cle | W | 10-5 | | Porcello | R | Porcello | | Romero,R | L |
| 8/6/2010 | | @ |  Mtl | W | 16-6 | | Purcey | L | Green,S | | Braden | L |
| 8/6/2010 | | | Oak | W | 8-2 | | Porcello | R | Porcello | | Tallet | L |
| 8/7/2010 | | @ | Mtl | W | 7-1 | | Zito | L | Zito | | Correia | R |
| 8/7/2010 | | | Oak | L | 2-6 | | Hammel | R | Hammel | | Perkins | L |
| 8/8/2010 | | @ | Mtl | W | 4-3 | 13 | Wolf | L | Nippert | | Jakubauskas | R |
| 8/8/2010 | | | Oak | L | 0-3 | | Wolf | L | Wolf | | Sabathia | L |
| 8/9/2010 | | @ | Mtl | W | 5-1 | 10 | Porcello | R | Nippert | | Jurrjens | R |
| 8/9/2010 | | | Oak | W | 10-6 | | Zito | L | Zito | | Hernandez,Li | R |
| 8/23/2010 | | | Mtl | W | 7-4 | | Wolf | L | Wolf | Bruney | Mortensen | R |
| 8/23/2010 | | @ | Sea | W | 10-5 | | Hammel | R | Hammel | | Bumgarner | L |
| 8/24/2010 | | | Mtl | W | 6-3 | | Zito | L | Nippert | Calero | Escobar,K | R |
| 8/24/2010 | | @ | Sea | L | 1-3 | | Zito | L | Zito | | Milton | L |
| 8/25/2010 | | | Mtl | W | 4-1 | | Purcey | L | Hoffman | Bruney | Santana,E | R |
| 8/25/2010 | | @ | Sea | W | 8-5 | | Wolf | L | Wolf | Hoffman | Gonzalez,G | L |
| 8/26/2010 | | | Mtl | W | 2-1 | | Hammel | R | Hammel | Calero | Braden | L |
| 8/26/2010 | | @ | Sea | W | 6-4 | | Porcello | R | Porcello | Nippert | Santana,J | L |
| 8/27/2010 | | | NYY | L | 6-9 | | Porcello | R | Bruney | | Park | R |
| 8/27/2010 | | @ | KCR | W | 13-5 | | Purcey | L | Purcey | | Martis | R |
| 8/28/2010 | | | NYY | L | 2-6 | | Wolf | L | Wolf | | McCarthy | R |
| 8/28/2010 | | @ | KCR | L | 1-6 | | Hammel | R | Hammel | | Meche | R |
| 8/29/2010 | | | NYY | L | 4-15 | | Zito | L | Zito | | Jurrjens | R |
| 8/29/2010 | | @ | KCR | W | 4-3 | | Zito | L | Zito | Calero | Hunter,Tom | R |
| 8/30/2010 | | | NYY | L | 5-17 | | Purcey | L | Purcey | | Carpenter,C | R |
| 8/30/2010 | | @ | KCR | L | 5-6 | 10 | Wolf | L | Hoffman | | Beckett | R |
| 9/7/2010 | | | Min | W | 7-6 | 12 | Hammel | R | Calero | | Liriano | L |
| 9/7/2010 | | @ | Det | W | 8-1 | | Niese | L | Niese | | French | L |
| 9/8/2010 | | | Min | L | 4-12 | | Purcey | L | Purcey | | Wakefield | R |
| 9/8/2010 | | @ | Det | W | 15-2 | | Hernandez,Da | R | Hernandez,Da | | Hill,S | R |
| 9/9/2010 | | | Min | L | 1-4 | | Porcello | R | Porcello | | Hernandez,F | R |
| 9/9/2010 | | @ | Det | W | 13-6 | | Purcey | L | Purcey | | Wellemeyer | R |
| 9/10/2010 | | | Was | L | 5-7 | 10 | Zito | L | Green,S | | Weaver,Jef | R |
| 9/10/2010 | | @ | Tex | L | 4-5 | | Porcello | R | Bruney | | Looper | R |
| 9/11/2010 | | | Was | W | 5-2 | | Wolf | L | Green,S | | Marquis | R |
| 9/11/2010 | | @ | Tex | W | 5-4 | | Hammel | R | Hammel | Calero | Lehr | R |
| 9/12/2010 | | | Was | L | 10-14 | | Hammel | R | Hammel | | de la Rosa | L |
| 9/12/2010 | | @ | Tex | W | 8-6 | | Niese | L | Nippert | Hoffman | Matusz | L |
| 9/13/2010 | | | Was | W | 3-1 | | Porcello | R | Rosa | Calero | Martinez,P | R |
| 9/13/2010 | | @ | Tex | L | 2-6 | | Hernandez,Da | R | Hernandez,Da | | Stammen | R |
| 9/22/2010 | | | Det | W | 5-4 | 10 | Purcey | L | Calero | | Wellemeyer | R |
| 9/22/2010 | | @ | Min | L | 8-9 | 14 | Zito | L | Hammel | | Davis,W | R |
| 9/23/2010 | | | Det | W | 11-6 | | Niese | L | Niese | | Rowland-Smith | L |
| 9/23/2010 | | @ | Min | L | 3-6 | | Hammel | R | Hammel | | Johnson,Jo | R |
| 9/24/2010 | | | Det | W | 15-4 | | Hammel | R | Hammel | | Lohse | R |
| 9/24/2010 | | @ | Min | L | 1-4 | | Niese | L | Niese | | Jackson,E | R |
| 9/25/2010 | | | Cle | L | 8-9 | | Porcello | R | Porcello | | Chacin | R |
| 9/25/2010 | | @ | Min | L | 3-7 | | Wolf | L | Wolf | | Liriano | L |
| 9/26/2010 | | | Cle | L | 2-5 | | Wolf | L | Wolf | | Verlander | R |
| 9/26/2010 | | @ | Min | L | 4-11 | | Hernandez,Da | R | Hernandez,Da | | Hernandez,F | R |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/8/2010 | | @ | Bos | W | Ethier | 3 | 2 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/8/2010 | | | KCR | W | Youkilis | 6 | 5 | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 4/9/2010 | | @ | Bos | W | Crosby | 5 | 1 | 3 | 0 | 1.000 | 3-0 | W3 | 3 |
| 4/9/2010 | | | KCR | L | | 4 | 7 | 3 | 1 | .750 | 3-1 | L1 | 4 |
| 4/10/2010 | | @ | Bos | W | Raburn | 3 | 1 | 4 | 1 | .800 | 4-1 | W1 | 5 |
| 4/10/2010 | | | KCR | W | Raburn | 8 | 7 | 5 | 1 | .833 | 5-1 | W2 | 6 |
| 4/11/2010 | | @ | Bos | L | | 1 | 7 | 5 | 2 | .714 | 5-2 | L1 | 7 |
| 4/11/2010 | | | KCR | W | Ethier | 3 | 1 | 6 | 2 | .750 | 6-2 | W1 | 8 |
| 4/12/2010 | | | Tor | W | | 3 | 1 | 7 | 2 | .778 | 7-2 | W2 | 9 |
| 4/12/2010 | | @ | Cle | W | Fields | 5 | 3 | 8 | 2 | .800 | 8-2 | W3 | 10 |
| 4/13/2010 | | | Tor | L | | 2 | 5 | 8 | 3 | .727 | 7-3 | L1 | 11 |
| 4/13/2010 | | @ | Cle | W | Francoeur | 2 | 1 | 9 | 3 | .750 | 7-3 | W1 | 12 |
| 4/14/2010 | | | Tor | W | Martin,R | 11 | 5 | 10 | 3 | .769 | 7-3 | W2 | 13 |
| 4/14/2010 | | @ | Cle | L | | 2 | 4 | 10 | 4 | .714 | 7-3 | L1 | 14 |
| 4/16/2010 | | | Min | L | | 3 | 9 | 10 | 5 | .667 | 6-4 | L2 | 15 |
| 4/16/2010 | | @ | Det | W | Raburn | 4 | 1 | 11 | 5 | .688 | 6-4 | W1 | 16 |
| 4/17/2010 | | | Min | L | | 5 | 6 | 11 | 6 | .647 | 6-4 | L1 | 17 |
| 4/17/2010 | | @ | Det | L | | 3 | 6 | 11 | 7 | .611 | 5-5 | L2 | 18 |
| 4/18/2010 | | | Min | W | Francoeur | 10 | 9 | 12 | 7 | .632 | 5-5 | W1 | 19 |
| 4/18/2010 | | @ | Det | W | Swisher | 3 | 0 | 13 | 7 | .650 | 5-5 | W2 | 20 |
| 4/23/2010 | | | Col | L | | 2 | 4 | 13 | 8 | .619 | 5-5 | L1 | 21 |
| 4/24/2010 | | | Col | W | Raburn | 7 | 0 | 14 | 8 | .636 | 5-5 | W1 | 22 |
| 4/25/2010 | | | Col | L | | 5 | 6 | 14 | 9 | .609 | 4-6 | L1 | 23 |
| 4/27/2010 | | | LAD | W | Francoeur | 3 | 1 | 15 | 9 | .625 | 5-5 | W1 | 24 |
| 4/28/2010 | | | LAD | L | | 3 | 9 | 15 | 10 | .600 | 5-5 | L1 | 25 |
| 4/29/2010 | | | LAD | W | Francoeur | 3 | 0 | 16 | 10 | .615 | 5-5 | W1 | 26 |
| 4/30/2010 | | @ | ChC | L | | 6 | 7 | 16 | 11 | .593 | 5-5 | L1 | 27 |
| 5/1/2010 | | @ | ChC | L | | 5 | 6 | 16 | 12 | .571 | 5-5 | L2 | 28 |
| 5/2/2010 | | @ | ChC | W | Youkilis | 4 | 3 | 17 | 12 | .586 | 5-5 | W1 | 29 |
| 5/3/2010 | | @ | Mil | W | Martin,R | 10 | 4 | 18 | 12 | .600 | 5-5 | W2 | 30 |
| 5/4/2010 | | @ | Mil | W | Youkilis | 7 | 4 | 19 | 12 | .613 | 6-4 | W3 | 31 |
| 5/5/2010 | | @ | Mil | W | Swisher | 6 | 3 | 20 | 12 | .625 | 6-4 | W4 | 32 |
| 5/7/2010 | | @ | NYY | W | Youkilis | 8 | 7 | 21 | 12 | .636 | 7-3 | W5 | 33 |
| 5/7/2010 | | | Tex | W | Nix,L | 3 | 1 | 22 | 12 | .647 | 7-3 | W6 | 34 |
| 5/8/2010 | | @ | NYY | W | Ethier | 8 | 4 | 23 | 12 | .657 | 8-2 | W7 | 35 |
| 5/8/2010 | | | Tex | W | | 10 | 5 | 24 | 12 | .667 | 8-2 | W8 | 36 |
| 5/9/2010 | | @ | NYY | L | | 4 | 5 | 24 | 13 | .649 | 8-2 | L1 | 37 |
| 5/9/2010 | | | Tex | L | | 3 | 4 | 24 | 14 | .632 | 8-2 | L2 | 38 |
| 5/10/2010 | | @ | NYY | W | Youkilis | 11 | 7 | 25 | 14 | .641 | 8-2 | W1 | 39 |
| 5/10/2010 | | | Tex | W | Youkilis | 5 | 4 | 26 | 14 | .650 | 8-2 | W2 | 40 |
| 5/27/2010 | | @ | Bal | L | | 1 | 8 | 26 | 15 | .634 | 7-3 | L1 | 41 |
| 5/27/2010 | | | LAA | L | | 3 | 5 | 26 | 16 | .619 | 6-4 | L2 | 42 |
| 5/28/2010 | | @ | Bal | L | | 2 | 3 | 26 | 17 | .605 | 5-5 | L3 | 43 |
| 5/28/2010 | | | LAA | W | Ethier | 7 | 3 | 27 | 17 | .614 | 5-5 | W1 | 44 |
| 5/29/2010 | | @ | Bal | W | Ethier | 12 | 4 | 28 | 17 | .622 | 5-5 | W2 | 45 |
| 5/29/2010 | | | LAA | W | Swisher | 4 | 2 | 29 | 17 | .630 | 5-5 | W3 | 46 |
| 5/30/2010 | | @ | Bal | L | | 0 | 4 | 29 | 18 | .617 | 5-5 | L1 | 47 |
| 5/30/2010 | | | LAA | L | | 2 | 6 | 29 | 19 | .604 | 5-5 | L2 | 48 |
| 5/31/2010 | | @ | Tor | W | Cabrera,O | 11 | 3 | 30 | 19 | .612 | 5-5 | W1 | 49 |
| 5/31/2010 | | | Cle | W | Swisher | 12 | 4 | 31 | 19 | .620 | 5-5 | W2 | 50 |
| 6/1/2010 | | @ | Tor | W | Youkilis | 4 | 2 | 32 | 19 | .627 | 6-4 | W3 | 51 |
| 6/1/2010 | | | Cle | L | | 5 | 6 | 32 | 20 | .615 | 6-4 | L1 | 52 |
| 6/2/2010 | | @ | Tor | L | | 4 | 7 | 32 | 21 | .604 | 6-4 | L2 | 53 |
| 6/2/2010 | | | Cle | L | | 1 | 5 | 32 | 22 | .593 | 5-5 | L3 | 54 |
| 6/4/2010 | | | Bos | W | Francoeur | 2 | 1 | 33 | 22 | .600 | 5-5 | W1 | 55 |
| 6/4/2010 | | @ | Oak | W | Diaz,R | 5 | 4 | 34 | 22 | .607 | 5-5 | W2 | 56 |
| 6/5/2010 | | | Bos | W | Cabrera,O | 9 | 4 | 35 | 22 | .614 | 6-4 | W3 | 57 |
| 6/5/2010 | | @ | Oak | L | | 4 | 7 | 35 | 23 | .603 | 6-4 | L1 | 58 |
| 6/6/2010 | | | Bos | W | Cabrera,O | 6 | 4 | 36 | 23 | .610 | 6-4 | W1 | 59 |
| 6/6/2010 | | @ | Oak | W | Cabrera,O | 5 | 4 | 37 | 23 | .617 | 6-4 | W2 | 60 |
| 6/7/2010 | | | Bos | L | | 2 | 3 | 37 | 24 | .607 | 5-5 | L1 | 61 |
| 6/7/2010 | | @ | Oak | W | Nix,L | 8 | 4 | 38 | 24 | .613 | 6-4 | W1 | 62 |
| 6/8/2010 | | | SDP | L | | 1 | 5 | 38 | 25 | .603 | 6-4 | L1 | 63 |
| 6/9/2010 | | | SDP | W | Swisher | 7 | 5 | 39 | 25 | .609 | 7-3 | W1 | 64 |
| 6/10/2010 | | | SDP | W | Cabrera,O | 5 | 4 | 40 | 25 | .615 | 7-3 | W2 | 65 |
| 6/11/2010 | | | SFG | L | | 7 | 9 | 40 | 26 | .606 | 6-4 | L1 | 66 |
| 6/12/2010 | | | SFG | L | | 4 | 6 | 40 | 27 | .597 | 5-5 | L2 | 67 |
| 6/13/2010 | | | SFG | L | | 3 | 9 | 40 | 28 | .588 | 5-5 | L3 | 68 |
| 6/15/2010 | | | Ari | L | | 2 | 7 | 40 | 29 | .580 | 4-6 | L4 | 69 |
| 6/16/2010 | | | Ari | W | Crosby | 10 | 9 | 41 | 29 | .586 | 4-6 | W1 | 70 |
| 6/17/2010 | | | Ari | L | | 2 | 11 | 41 | 30 | .577 | 4-6 | L1 | 71 |
| 6/18/2010 | | @ | Cin | L | | 2 | 3 | 41 | 31 | .569 | 3-7 | L2 | 72 |
| 6/19/2010 | | @ | Cin | L | | 4 | 8 | 41 | 32 | .562 | 3-7 | L3 | 73 |
| 6/20/2010 | | @ | Cin | L | | 9 | 10 | 41 | 33 | .554 | 2-8 | L4 | 74 |
| 6/21/2010 | | @ | Hou | W | Swisher | 4 | 1 | 42 | 33 | .560 | 2-8 | W1 | 75 |
| 6/22/2010 | | @ | Hou | W | Raburn | 9 | 8 | 43 | 33 | .566 | 3-7 | W2 | 76 |
| 6/23/2010 | | @ | Hou | W | Ethier | 9 | 4 | 44 | 33 | .571 | 4-6 | W3 | 77 |
| 6/25/2010 | | @ | StL | W | Francoeur | 6 | 4 | 45 | 33 | .577 | 5-5 | W4 | 78 |
| 6/26/2010 | | @ | StL | W | Nix,L | 5 | 3 | 46 | 33 | .582 | 6-4 | W5 | 79 |
| 6/27/2010 | | @ | StL | L | | 4 | 8 | 46 | 34 | .575 | 5-5 | L1 | 80 |
| 7/12/2010 | | | Det | W | Nix,L | 9 | 3 | 47 | 34 | .580 | 6-4 | W1 | 81 |
| 7/12/2010 | | @ | Min | L | | 1 | 5 | 47 | 35 | .573 | 6-4 | L1 | 82 |
| 7/13/2010 | | | Det | W | Swisher | 3 | 2 | 48 | 35 | .578 | 7-3 | W1 | 83 |
| 7/13/2010 | | @ | Min | L | | 1 | 5 | 48 | 36 | .571 | 7-3 | L1 | 84 |
| 7/14/2010 | | | Det | W | Youkilis | 5 | 0 | 49 | 36 | .576 | 7-3 | W1 | 85 |
| 7/14/2010 | | @ | Min | L | | 3 | 7 | 49 | 37 | .570 | 6-4 | L1 | 86 |
| 7/15/2010 | | | Sea | W | Raburn | 5 | 1 | 50 | 37 | .575 | 6-4 | W1 | 87 |
| 7/15/2010 | | @ | Was | W | Nix,L | 4 | 3 | 51 | 37 | .580 | 6-4 | W2 | 88 |
| 7/16/2010 | | | Sea | L | | 3 | 7 | 51 | 38 | .573 | 5-5 | L1 | 89 |
| 7/16/2010 | | @ | Was | W | Swisher | 6 | 1 | 52 | 38 | .578 | 6-4 | W1 | 90 |
| 7/17/2010 | | | Sea | W | Ethier | 5 | 4 | 53 | 38 | .582 | 6-4 | W2 | 91 |
| 7/17/2010 | | @ | Was | W | Ethier | 5 | 4 | 54 | 38 | .587 | 7-3 | W3 | 92 |
| 7/18/2010 | | | Sea | W | Ethier | 7 | 3 | 55 | 38 | .591 | 7-3 | W4 | 93 |
| 7/18/2010 | | @ | Was | W | Nix,L | 3 | 1 | 56 | 38 | .596 | 8-2 | W5 | 94 |
| 7/20/2010 | | | Bal | W | Schumaker | 8 | 5 | 57 | 38 | .600 | 8-2 | W6 | 95 |
| 7/20/2010 | | @ | LAA | W | Swisher | 8 | 7 | 58 | 38 | .604 | 9-1 | W7 | 96 |
| 7/21/2010 | | | Bal | W | Cabrera,O | 12 | 5 | 59 | 38 | .608 | 9-1 | W8 | 97 |
| 7/21/2010 | | @ | LAA | L | | 9 | 13 | 59 | 39 | .602 | 8-2 | L1 | 98 |
| 7/22/2010 | | | Bal | W | Cabrera,O | 5 | 4 | 60 | 39 | .606 | 9-1 | W1 | 99 |
| 7/22/2010 | | @ | LAA | W | | 12 | 7 | 61 | 39 | .610 | 9-1 | W2 | 100 |
| 7/23/2010 | | | Bal | W | Ethier | 4 | 3 | 62 | 39 | .614 | 9-1 | W3 | 101 |
| 7/23/2010 | | @ | LAA | W | Martin,R | 6 | 3 | 63 | 39 | .618 | 9-1 | W4 | 102 |
| 7/30/2010 | | @ | Tor | L | | 1 | 10 | 63 | 40 | .612 | 8-2 | L1 | 103 |
| 7/30/2010 | | | Cle | L | | 1 | 7 | 63 | 41 | .606 | 7-3 | L2 | 104 |
| 7/31/2010 | | @ | Tor | L | | 4 | 8 | 63 | 42 | .600 | 6-4 | L3 | 105 |
| 7/31/2010 | | | Cle | L | | 5 | 6 | 63 | 43 | .594 | 5-5 | L4 | 106 |
| 8/1/2010 | | @ | Tor | W | Thome | 12 | 6 | 64 | 43 | .598 | 5-5 | W1 | 107 |
| 8/1/2010 | | | Cle | L | | 1 | 16 | 64 | 44 | .593 | 5-5 | L1 | 108 |
| 8/2/2010 | | | Tor | W | Raburn | 8 | 7 | 65 | 44 | .596 | 5-5 | W1 | 109 |
| 8/2/2010 | | @ | Cle | W | Diaz,R | 10 | 3 | 66 | 44 | .600 | 5-5 | W2 | 110 |
| 8/3/2010 | | | Tor | W | Thome | 3 | 2 | 67 | 44 | .604 | 5-5 | W3 | 111 |
| 8/3/2010 | | @ | Cle | W | Thome | 9 | 3 | 68 | 44 | .607 | 5-5 | W4 | 112 |
| 8/4/2010 | | | Tor | L | | 1 | 3 | 68 | 45 | .602 | 5-5 | L1 | 113 |
| 8/4/2010 | | @ | Cle | W | Youkilis | 10 | 5 | 69 | 45 | .605 | 6-4 | W1 | 114 |
| 8/6/2010 | | @ | Mtl | W | Fields | 16 | 6 | 70 | 45 | .609 | 7-3 | W2 | 115 |
| 8/6/2010 | | | Oak | W | Swisher | 8 | 2 | 71 | 45 | .612 | 8-2 | W3 | 116 |
| 8/7/2010 | | @ | Mtl | W | Cabrera,O | 7 | 1 | 72 | 45 | .615 | 8-2 | W4 | 117 |
| 8/7/2010 | | | Oak | L | | 2 | 6 | 72 | 46 | .610 | 8-2 | L1 | 118 |
| 8/8/2010 | | @ | Mtl | W | Cabrera,O | 4 | 3 | 73 | 46 | .613 | 8-2 | W1 | 119 |
| 8/8/2010 | | | Oak | L | | 0 | 3 | 73 | 47 | .608 | 7-3 | L1 | 120 |
| 8/9/2010 | | @ | Mtl | W | Diaz,R | 5 | 1 | 74 | 47 | .612 | 7-3 | W1 | 121 |
| 8/9/2010 | | | Oak | W | Cabrera,O | 10 | 6 | 75 | 47 | .615 | 7-3 | W2 | 122 |
| 8/23/2010 | | | Mtl | W | Ethier | 7 | 4 | 76 | 47 | .618 | 8-2 | W3 | 123 |
| 8/23/2010 | | @ | Sea | W | Fields | 10 | 5 | 77 | 47 | .621 | 8-2 | W4 | 124 |
| 8/24/2010 | | | Mtl | W | Francoeur | 6 | 3 | 78 | 47 | .624 | 8-2 | W5 | 125 |
| 8/24/2010 | | @ | Sea | L | | 1 | 3 | 78 | 48 | .619 | 7-3 | L1 | 126 |
| 8/25/2010 | | | Mtl | W | Swisher | 4 | 1 | 79 | 48 | .622 | 7-3 | W1 | 127 |
| 8/25/2010 | | @ | Sea | W | Fields | 8 | 5 | 80 | 48 | .625 | 8-2 | W2 | 128 |
| 8/26/2010 | | | Mtl | W | Swisher | 2 | 1 | 81 | 48 | .628 | 8-2 | W3 | 129 |
| 8/26/2010 | | @ | Sea | W | Raburn | 6 | 4 | 82 | 48 | .631 | 9-1 | W4 | 130 |
| 8/27/2010 | | | NYY | L | | 6 | 9 | 82 | 49 | .626 | 8-2 | L1 | 131 |
| 8/27/2010 | | @ | KCR | W | Youkilis | 13 | 5 | 83 | 49 | .629 | 8-2 | W1 | 132 |
| 8/28/2010 | | | NYY | L | | 2 | 6 | 83 | 50 | .624 | 7-3 | L1 | 133 |
| 8/28/2010 | | @ | KCR | L | | 1 | 6 | 83 | 51 | .619 | 6-4 | L2 | 134 |
| 8/29/2010 | | | NYY | L | | 4 | 15 | 83 | 52 | .615 | 5-5 | L3 | 135 |
| 8/29/2010 | | @ | KCR | W | Barton,D | 4 | 3 | 84 | 52 | .618 | 6-4 | W1 | 136 |
| 8/30/2010 | | | NYY | L | | 5 | 17 | 84 | 53 | .613 | 5-5 | L1 | 137 |
| 8/30/2010 | | @ | KCR | L | | 5 | 6 | 84 | 54 | .609 | 4-6 | L2 | 138 |
| 9/7/2010 | | | Min | W | Cabrera,O | 7 | 6 | 85 | 54 | .612 | 4-6 | W1 | 139 |
| 9/7/2010 | | @ | Det | W | Francoeur | 8 | 1 | 86 | 54 | .614 | 4-6 | W2 | 140 |
| 9/8/2010 | | | Min | L | | 4 | 12 | 86 | 55 | .610 | 4-6 | L1 | 141 |
| 9/8/2010 | | @ | Det | W | Schumaker | 15 | 2 | 87 | 55 | .613 | 4-6 | W1 | 142 |
| 9/9/2010 | | | Min | L | | 1 | 4 | 87 | 56 | .608 | 4-6 | L1 | 143 |
| 9/9/2010 | | @ | Det | W | Martin,R | 13 | 6 | 88 | 56 | .611 | 5-5 | W1 | 144 |
| 9/10/2010 | | | Was | L | | 5 | 7 | 88 | 57 | .607 | 5-5 | L1 | 145 |
| 9/10/2010 | | @ | Tex | L | | 4 | 5 | 88 | 58 | .603 | 4-6 | L2 | 146 |
| 9/11/2010 | | | Was | W | Schumaker | 5 | 2 | 89 | 58 | .605 | 5-5 | W1 | 147 |
| 9/11/2010 | | @ | Tex | W | Youkilis | 5 | 4 | 90 | 58 | .608 | 6-4 | W2 | 148 |
| 9/12/2010 | | | Was | L | | 10 | 14 | 90 | 59 | .604 | 5-5 | L1 | 149 |
| 9/12/2010 | | @ | Tex | W | Swisher | 8 | 6 | 91 | 59 | .607 | 5-5 | W1 | 150 |
| 9/13/2010 | | | Was | W | Ethier | 3 | 1 | 92 | 59 | .609 | 6-4 | W2 | 151 |
| 9/13/2010 | | @ | Tex | L | | 2 | 6 | 92 | 60 | .605 | 5-5 | L1 | 152 |
| 9/22/2010 | | | Det | W | Cabrera,O | 5 | 4 | 93 | 60 | .608 | 6-4 | W1 | 153 |
| 9/22/2010 | | @ | Min | L | | 8 | 9 | 93 | 61 | .604 | 5-5 | L1 | 154 |
| 9/23/2010 | | | Det | W | Youkilis | 11 | 6 | 94 | 61 | .606 | 6-4 | W1 | 155 |
| 9/23/2010 | | @ | Min | L | | 3 | 6 | 94 | 62 | .603 | 6-4 | L1 | 156 |
| 9/24/2010 | | | Det | W | Cabrera,O | 15 | 4 | 95 | 62 | .605 | 6-4 | W1 | 157 |
| 9/24/2010 | | @ | Min | L | | 1 | 4 | 95 | 63 | .601 | 5-5 | L1 | 158 |
| 9/25/2010 | | | Cle | L | | 8 | 9 | 95 | 64 | .597 | 5-5 | L2 | 159 |
| 9/25/2010 | | @ | Min | L | | 3 | 7 | 95 | 65 | .594 | 4-6 | L3 | 160 |
| 9/26/2010 | | | Cle | L | | 2 | 5 | 95 | 66 | .590 | 3-7 | L4 | 161 |
| 9/26/2010 | | @ | Min | L | | 4 | 11 | 95 | 67 | .586 | 3-7 | L5 | 162 |