League team vs team -- American League
Regular season
| 2010 American League |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Mtl | Was | Bal | Bos | NYY | Tor | Cle | Det | Min | ChW | LAA | Oak | Sea | Tex | KCR |
| Mtl | | 1-11 | 5-11 | 5-7 | 3-9 | 5-3 | 2-6 | 3-5 | 2-6 | 0-8 | 2-6 | 3-5 | 6-2 | 2-6 | 4-4 |
| Was | 11-1 | | 7-5 | 10-4 | 5-9 | 7-1 | 6-2 | 4-4 | 4-4 | 2-6 | 7-1 | 6-2 | 4-4 | 6-2 | 5-3 |
| Bal | 11-5 | 5-7 | | 5-7 | 1-11 | 6-2 | 5-3 | 6-2 | 2-6 | 3-5 | 5-3 | 2-6 | 3-5 | 3-5 | 2-6 |
| Bos | 7-5 | 4-10 | 7-5 | | 4-10 | 7-1 | 5-3 | 8-0 | 4-4 | 2-6 | 6-2 | 5-3 | 5-3 | 6-2 | 5-3 |
| NYY | 9-3 | 9-5 | 11-1 | 10-4 | | 7-1 | 5-3 | 6-2 | 2-6 | 5-3 | 5-3 | 6-2 | 4-4 | 4-4 | 5-3 |
| | | | | | | | | | | | | | | | |
| Tor | 3-5 | 1-7 | 2-6 | 1-7 | 1-7 | | 7-5 | 12-4 | 2-10 | 5-7 | 5-3 | 5-3 | 4-4 | 5-3 | 3-5 |
| Cle | 6-2 | 2-6 | 3-5 | 3-5 | 3-5 | 5-7 | | 11-1 | 6-8 | 8-6 | 4-4 | 6-2 | 4-4 | 5-3 | 4-4 |
| Det | 5-3 | 4-4 | 2-6 | 0-8 | 2-6 | 4-12 | 1-11 | | 4-8 | 1-11 | 4-4 | 1-7 | 2-6 | 3-5 | 2-6 |
| Min | 6-2 | 4-4 | 6-2 | 4-4 | 6-2 | 10-2 | 8-6 | 8-4 | | 12-2 | 5-3 | 4-4 | 8-0 | 5-3 | 5-3 |
| ChW | 8-0 | 6-2 | 5-3 | 6-2 | 3-5 | 7-5 | 6-8 | 11-1 | 2-12 | | 5-3 | 5-3 | 6-2 | 5-3 | 5-3 |
| | | | | | | | | | | | | | | | |
| LAA | 6-2 | 1-7 | 3-5 | 2-6 | 3-5 | 3-5 | 4-4 | 4-4 | 3-5 | 3-5 | | 5-11 | 5-7 | 6-6 | 5-7 |
| Oak | 5-3 | 2-6 | 6-2 | 3-5 | 2-6 | 3-5 | 2-6 | 7-1 | 4-4 | 3-5 | 11-5 | | 6-6 | 8-4 | 1-11 |
| Sea | 2-6 | 4-4 | 5-3 | 3-5 | 4-4 | 4-4 | 4-4 | 6-2 | 0-8 | 2-6 | 7-5 | 6-6 | | 8-6 | 9-5 |
| Tex | 6-2 | 2-6 | 5-3 | 2-6 | 4-4 | 3-5 | 3-5 | 5-3 | 3-5 | 3-5 | 6-6 | 4-8 | 6-8 | | 4-10 |
| KCR | 4-4 | 3-5 | 6-2 | 3-5 | 3-5 | 5-3 | 4-4 | 6-2 | 3-5 | 3-5 | 7-5 | 11-1 | 5-9 | 10-4 | |
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